School of Pharmacy, Gannan Medical University, Ganzhou, 341000, Jiangxi Province, P. R. China.
Org Biomol Chem. 2022 Mar 30;20(13):2621-2625. doi: 10.1039/d2ob00122e.
An iridium complex-catalyzed reductive etherification of α,β-unsaturated ketones and aldehydes with primary alcohols is presented, affording allyl ethers in excellent yields. Deuterated and control experiments showed that this etherification transformation proceeded through a cascade transfer hydrogenation and alcohol condensation process. Moreover, the utility of this protocol is evidenced by the gram-scale performance.
报道了铱配合物催化的α,β-不饱和酮和醛与伯醇的还原醚化反应，以优异的收率得到了烯丙基醚。氘代和对照实验表明，这种醚化转化是通过级联转移氢化和醇缩合过程进行的。此外，该方案的实用性通过克级规模的性能得到了证明。
