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体外膜肺氧合在心包切开术后伴或不伴主动脉内球囊反搏。

Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation With and Without Intra-Aortic Balloon Pump.

机构信息

Department of Cardiothoracic Surgery, Skane University Hospital and Lund University, Lund, Sweden.

Clinica Montevergine, GVM Care & Research, Mercogliano, Italy; Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

出版信息

J Cardiothorac Vasc Anesth. 2022 Aug;36(8 Pt B):2876-2883. doi: 10.1053/j.jvca.2022.02.006. Epub 2022 Feb 11.

Abstract

OBJECTIVES

To compare the outcomes of patients with postcardiotomy shock treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) only compared with VA-ECMO and intra-aortic balloon pump (IABP).

DESIGN

A retrospective multicenter registry study.

SETTING

At 19 cardiac surgery units.

PARTICIPANTS

A total of 615 adult patients who required VA-ECMO from 2010 to 2018. The patients were divided into 2 groups depending on whether they received VA-ECMO only (ECMO only group) or VA-ECMO plus IABP (ECMO-IABP group).

MEASUREMENTS AND MAIN RESULTS

The overall series mean age was 63 ± 13 years, and 33% were female. The ECMO-only group included 499 patients, and 116 patients were in the ECMO-IABP group. Urgent and/or emergent procedures were more common in the ECMO-only group. Central cannulation was performed in 47% (n = 54) in the ECMO-IABP group compared to 27% (n = 132) in the ECMO-only group. In the ECMO-IABP group, 58% (n = 67) were successfully weaned from ECMO, compared to 46% (n = 231) in the ECMO-only group (p = 0.026). However, in-hospital mortality was 63% in the ECMO-IABP group compared to 65% in the ECMO-only group (p = 0.66). Among 114 propensity score-matched pairs, ECMO-IABP group had comparable weaning rates (57% v 53%, p = 0.51) and in-hospital mortality (64% v 58%, p = 0.78).

CONCLUSIONS

This multicenter study showed that adjunctive IABP did not translate into better outcomes in patients treated with VA-ECMO for postcardiotomy shock.

摘要

目的

比较单纯使用体外膜肺氧合(VA-ECMO)与联合使用主动脉内球囊反搏(IABP)治疗心脏手术后休克患者的结局。

设计

回顾性多中心注册研究。

地点

19 个心脏外科中心。

参与者

2010 年至 2018 年期间,共 615 名需要 VA-ECMO 的成年患者。根据是否接受单纯 VA-ECMO(ECMO 组)或 VA-ECMO 联合 IABP(ECMO-IABP 组),将患者分为 2 组。

测量和主要结果

整个系列的平均年龄为 63±13 岁,33%为女性。ECMO 组包括 499 例患者,ECMO-IABP 组包括 116 例患者。ECMO 组更常进行紧急和/或紧急手术。ECMO-IABP 组中心插管占 47%(n=54),而 ECMO 组仅占 27%(n=132)。ECMO-IABP 组 58%(n=67)成功撤离 ECMO,而 ECMO 组仅为 46%(n=231)(p=0.026)。然而,ECMO-IABP 组的院内死亡率为 63%,而 ECMO 组为 65%(p=0.66)。在 114 对倾向评分匹配的对中,ECMO-IABP 组的撤机率(57%比 53%,p=0.51)和院内死亡率(64%比 58%,p=0.78)相当。

结论

这项多中心研究表明,在心脏手术后休克患者中,联合使用 IABP 并不能改善 VA-ECMO 的治疗效果。

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