Medical Scientist Training Program, Columbia University Irving Medical Center, NY 10032, USA.
New York State Psychiatric Institute, NY 10032, USA; Department of Psychiatry, Columbia University Irving Medical Center, NY 10032, USA.
Neuroimage. 2022 Jun;253:119100. doi: 10.1016/j.neuroimage.2022.119100. Epub 2022 Mar 15.
When exposed to the same sensory event, some individuals are bound to have less typical experiences than others. Previous research has investigated this phenomenon by showing that the typicality of one's sensory experience is associated with the typicality of their stimulus-evoked brain activity (as measured by intersubject correlation, or ISC). Individual differences in ISC have recently been attributed to variability in focal neural processing. However, the extent to which these differences reflect purely intra-regional variability versus variation in the brain's baseline ability to transmit information between regions has yet to be established. Here, we show that an individual's degree and spatial distribution of ISC are closely related to their brain's functional organization at rest. Using resting state and movie watching fMRI data from the Human Connectome Project, we reveal that resting state functional connectivity (RSFC) profiles can be used to predict cortex-wide ISC. Similar region-level analyses demonstrate that the levels of ISC exhibited by brain regions during movie watching are associated with their connectivity to other regions at rest, and that the nature of these connectivity-activity relationships varies as a function of regional roles in sensory information processing. Finally, we show that an individual's unique spatial distribution of ISC, independent of its magnitude, is also related to their RSFC profile. These findings contextualize reports of localized individual differences in ISC as potentially reflecting larger, network-level alterations in resting brain function and detail how the brain's ability to process complex sensory information is linked to its baseline functional organization.
当暴露在相同的感官事件中时，一些个体的体验必然比其他人不那么典型。先前的研究通过表明一个人的感官体验的典型性与他们的刺激引发的大脑活动的典型性（通过主体间相关性或 ISC 来衡量）有关，从而研究了这种现象。ISC 的个体差异最近归因于焦点神经处理的可变性。然而，这些差异在多大程度上反映了纯粹的区域内变异性，还是反映了大脑在区域之间传输信息的基线能力的变异性，仍有待确定。在这里，我们表明个体的 ISC 程度和空间分布与他们大脑在休息时的功能组织密切相关。使用来自人类连接组计划的静息状态和观看电影的 fMRI 数据，我们揭示了静息状态功能连接（RSFC）图谱可以用于预测皮层范围的 ISC。类似的区域水平分析表明，在观看电影时大脑区域表现出的 ISC 水平与它们在静息时与其他区域的连接有关，并且这些连接-活动关系的性质随着区域在感官信息处理中的作用而变化。最后，我们表明个体的 ISC 独特的空间分布，独立于其大小，也与他们的 RSFC 图谱有关。这些发现将 ISC 中的局部个体差异的报告置于背景中，表明静息大脑功能的更大的、网络水平的改变，并详细说明了大脑处理复杂感官信息的能力与它的基线功能组织之间的联系。
