Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Clínica, Faculty of Medicine, Graduate Program in Psychiatry and Behavioral Sciences, Porto Alegre, Brazil.
Graduate Program in Health Promotion, Cesumar University, Maringá, Paraná, Brazil.
Sci Rep. 2022 Mar 18;12(1):4710. doi: 10.1038/s41598-022-08729-5.
Access to postmortem brain tissue can be valuable in refining knowledge on the pathophysiology and genetics of neuropsychiatric disorders. Obtaining postmortem consent for the donation after death by suicide can be difficult, as families may be overwhelmed by a violent and unexpected death. Examining the process of brain donation can inform on how the request can best be conducted. This is a qualitative study with in-depth interviews with forty-one people that were asked to consider brain donation-32 who had consented to donation and 9 who refused it. Data collection and analyses were carried out according to grounded theory. Five key themes emerged from data analysis: the context of the families, the invitation to talk to the research team, the experience with the request protocol, the participants' assessment of the experience, and their participation in the study as an opportunity to heal. The participants indicated that a brain donation request that is respectful and tactful can be made without adding to the family distress brought on by suicide and pondering brain donation was seen as an opportunity to transform the meaning of the death and invest it with a modicum of solace for being able to contribute to research.
获取死后大脑组织对于深化神经精神疾病的病理生理学和遗传学知识非常有价值。对于自杀死亡者的死后捐赠，获得家属同意可能非常困难，因为他们可能会被亲人突然而暴力的死亡所淹没。研究大脑捐赠的过程可以为如何最好地进行捐赠请求提供信息。这是一项定性研究，对 41 人进行了深入访谈，这些人被要求考虑大脑捐赠——32 人同意捐赠，9 人拒绝捐赠。数据收集和分析是根据扎根理论进行的。数据分析中出现了五个关键主题：家庭的背景、与研究小组交谈的邀请、对请求协议的体验、参与者对体验的评估，以及他们作为治愈机会参与研究。参与者表示，在不增加自杀带来的家庭痛苦的情况下，可以尊重和巧妙地提出大脑捐赠请求，思考大脑捐赠可以被视为一个机会，改变死亡的意义，并为能够为研究做出贡献而获得一些安慰。
