Gastroenterologist in training, University hospital of Ghent.
Department of anatomopathology Sint-Andries hospital Tielt.
Acta Gastroenterol Belg. 2022 Jan-Mar;85(1):80-84. doi: 10.51821/85.1.8499.
Amyloidosis is a very rare condition, which, due to its rarity, is often missed or diagnosed in an advanced stage of the disease, causing significant morbidity and mortality. In this review we describe the existing types of amyloidosis focusing on the gastro-intestinal tract. Amyloidosis occurs when abnormal protein fibrils (amyloid) deposit in the muscularis mucosae. This can cause an array of symptoms ranging from (in order of occurrence): gastro-intestinal bleeding, heartburn, unintentional weight loss, early satiety, constipation, diarrhea, nausea, vomiting and fecal incontinence (1). Treatment is focused on the underlying condition (if any) causing the production and deposition of the abnormal fibrils, in combination of symptomatic treatment.
淀粉样变性是一种非常罕见的病症，由于其罕见性，常被漏诊或在疾病晚期才被诊断，导致发病率和死亡率显著升高。在本综述中，我们描述了现有的淀粉样变性类型，重点关注胃肠道。淀粉样变性是指异常蛋白纤维（淀粉样物质）在黏膜肌层沉积。这会引起一系列症状，按发生频率依次为：胃肠出血、胃灼热、非故意体重减轻、早饱、便秘、腹泻、恶心、呕吐和大便失禁（1）。治疗侧重于引起异常纤维产生和沉积的潜在疾病（如有），并结合对症治疗。
