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利用β1 - β2受体阻滞剂普萘洛尔(心得安)的抗交感神经作用,联合地西泮及尿液酸化,对急慢性肾上腺素能中毒危机进行治疗的方案。

Treatment plan for acute and chronic adrenergic poisoning crisis utilizing sympatholytic effects of the B1-B2 receptor site blocker propranolol (Inderal) in concert with diazepam and urine acidification.

作者信息

Rappolt R T, Gay G R, Soman M, Kobernick M

出版信息

Clin Toxicol. 1979;14(1):55-69. doi: 10.3109/15563657909030114.

DOI:10.3109/15563657909030114
PMID:35305
Abstract

In a large series of patients who have abused a variety of commercially available "amphetamine-like" agents as well as "street drugs" with CNS stimulant activity, the specific lytic effects of propranolol (Inderal) were utilized to reverse the dangerous hyperkinetic cardiovascular and frightening CNS phenomena noted in these non-comatose individuals. Presented here is a logical and clinically proven mode of therapy by which the authors have consistently, successfully, and safely managed such patients in "adrenergic crisis" by judicious titration of electrolytes, propranolol, and diazepam.

摘要

在一大组滥用各种市售“苯丙胺样”药物以及具有中枢神经系统兴奋活性“街头毒品”的患者中,利用普萘洛尔(心得安)的特异性溶解作用来逆转这些非昏迷个体中出现的危险的高动力性心血管现象和令人恐惧的中枢神经系统症状。本文介绍了一种合乎逻辑且经临床验证的治疗模式,作者通过明智地滴定电解质、普萘洛尔和地西泮,始终如一地、成功且安全地处理处于“肾上腺素能危象”的此类患者。

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Treatment plan for acute and chronic adrenergic poisoning crisis utilizing sympatholytic effects of the B1-B2 receptor site blocker propranolol (Inderal) in concert with diazepam and urine acidification.利用β1 - β2受体阻滞剂普萘洛尔(心得安)的抗交感神经作用,联合地西泮及尿液酸化,对急慢性肾上腺素能中毒危机进行治疗的方案。
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引用本文的文献

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Sympathomimetic Toxidromes and Other Pharmacological Causes of Acute Hypertension.拟交感毒性综合征和其他引起急性高血压的药理学原因。
Curr Hypertens Rep. 2018 Feb 24;20(1):8. doi: 10.1007/s11906-018-0807-9.
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Acute myocardial infarction associated with cocaine withdrawal.与可卡因戒断相关的急性心肌梗死
CMAJ. 1991 May 1;144(9):1139-40.