Chen Dawei, Wang Tao, Ye Xin, Xu Xiuzhang, Xia Wenjie, Fu Yongshui
Institute of Blood Transfusion, Guangzhou Blood Center, Guangzhou, Guangdong, China.
Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Stem Cell Res. 2022 May;61:102749. doi: 10.1016/j.scr.2022.102749. Epub 2022 Mar 14.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) caused by anti-CD36 isoantibodies is a common disease and the frequency of type I CD36 deficiency is relatively high in eastern Asian populations.Currently, patient-specific induced pluripotent stem cells (hiPSC) are believed to be useful tools for studying anti-CD36 mediated FNAIT and finding new therapeutic approaches to the disease.We generated an iPSC line from peripheral blood mononuclear cells of a patient carrying a 329-330delAC of the CD36 gene.The iPSC expressed pluripotency markers, gave rise to derivatives of three germ layers during spontaneous differentiation, had a normal karyotype, and retained the patient-specific mutation.
由抗CD36同种抗体引起的胎儿和新生儿同种免疫性血小板减少症（FNAIT）是一种常见疾病，在东亚人群中I型CD36缺乏症的发生率相对较高。目前，患者特异性诱导多能干细胞（hiPSC）被认为是研究抗CD36介导的FNAIT以及寻找该疾病新治疗方法的有用工具。我们从一名携带CD36基因329 - 330delAC突变的患者外周血单个核细胞中生成了一个iPSC系。该iPSC表达多能性标志物，在自发分化过程中产生三个胚层的衍生物，具有正常核型，并保留了患者特异性突变。
