无整合诱导多能干细胞系来源于携带 APOE-epsilon4/epsilon4 等位基因的 62 岁男性供者。
Integration-free induced pluripotent stem cell line derived from a 62-years-old male donor with APOE-epsilon4/epsilon4 alleles.
机构信息
Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China.
Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Department of Neurology, The First Hospital of Hebei Medical University, Hebei Province 050017, China.
出版信息
Stem Cell Res. 2022 May;61:102746. doi: 10.1016/j.scr.2022.102746. Epub 2022 Mar 12.
The ε4 allele of the Apolipoprotein E gene (APOE4) continues to be the strongest genetic risk factor associated with sporadic Alzheimer's disease since its discovery compared to the most common ε3 allele. Nevertheless, there is a lack of APOE4-mutant human neuronal models in vitroor in vivo. Hence, we presented an iPSC line of an APOE-ε4/ε4 alleles carrier, a male donor suffering from Alzheimer's disease combined with cerebral infarction. The established iPSC line showed standard characteristics of pluripotency. Collectively, the present study provides a useful resource to reveal the phenotype and explore the mechanism of APOE4 related Alzheimer's disease.
载脂蛋白 E 基因（APOE）的 ε4 等位基因（APOE4）是目前发现的与散发性阿尔茨海默病最相关的最强遗传风险因素，与最常见的 ε3 等位基因相比。然而，目前在体外或体内缺乏 APOE4 突变的人类神经元模型。因此，我们提供了一名携带 APOE-ε4/ε4 等位基因的阿尔茨海默病合并脑梗死男性供体的 iPSC 系。已建立的 iPSC 系表现出多能性的标准特征。总之，本研究为揭示 APOE4 相关阿尔茨海默病的表型和探讨其机制提供了有用的资源。
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