Liu Hanyuan, Li Xiao, Li Haiyang, Feng Lei, Sun Guangshun, Sun Guoqiang, Wu Liangliang, Hu Yun, Liu Li, Wang Hanjin
Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
School of Public Health, Fudan University, Shanghai, China.
Biomed Pharmacother. 2022 May;149:112824. doi: 10.1016/j.biopha.2022.112824. Epub 2022 Mar 17.
Breast cancer is the most common malignant tumor in women and the leading cause of cancer death in women. About 30% of breast cancer patients have metastasis every year, which greatly increases the mortality rate of breast cancer. The main target organs for metastasis are bone, brain, liver and lung. The breast cancer liver metastasis (BCLM) mechanism is not fully clarified. This is a complex process involving multiple factors, which is not only related to the microenvironment of the primary tumor and liver, but also regulated by a variety of signaling pathways. Clarifying these mechanisms is of great help to guide clinical treatment. With the in-depth study of BCLM, a variety of new treatment schemes such as targeted therapy and endocrine therapy provide new ideas for the cure of BCLM. In this review, we will summarize the molecular mechanism and treatment of BCLM.
乳腺癌是女性最常见的恶性肿瘤，也是女性癌症死亡的主要原因。每年约有30%的乳腺癌患者发生转移，这大大增加了乳腺癌的死亡率。转移的主要靶器官是骨、脑、肝和肺。乳腺癌肝转移（BCLM）的机制尚未完全阐明。这是一个涉及多种因素的复杂过程，不仅与原发肿瘤和肝脏的微环境有关，还受多种信号通路的调控。阐明这些机制对指导临床治疗有很大帮助。随着对BCLM研究的深入，靶向治疗和内分泌治疗等多种新的治疗方案为BCLM的治愈提供了新思路。在这篇综述中，我们将总结BCLM的分子机制和治疗方法。
