Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Department of Clinical Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic.
Eur J Haematol. 2022 Jul;109(1):75-82. doi: 10.1111/ejh.13771. Epub 2022 Mar 24.
Our aim was to correlate serum levels of selected markers of bone metabolism and bone marrow microenvironment to cytogenetic changes in patients with multiple myeloma (MM).
We assed cytogenetic changes in 308 patients and correlated them with the following levels of bone marrow metabolism: thymidine kinase (TK), β2-microglobulin (b-2-m), Dickkopf-1 protein (DKK-1), C-terminal telopeptide collagen-I (ICTP), N-terminal propeptide of type I procollagen (PINP), receptor for interleukin 6 (rIL-6), vascular cell adhesive molecule-1 (VCAM), soluble intercellular adhesion molecule-1, osteoprotegerin (OPG), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), syndecan-1 (SYN-1) and Fas antigen.
Individuals with delRB1 had lower levels of OPG (M = 7.39 vs. 5.46 pmol/L, p = .025) and VEGF (M = 304 vs. 196 pg/ml; p = .036). t(14;16) was associated with higher β2m levels (M = 7.59 vs. 4.13 mg/L; p = .022) and lower DKK-1 levels (M = 4465 ng/L vs. 12,593). The presence of 1q21 gain was associated with higher levels of TK (M = 100.0 vs. 11.0 IU/L, p = .026) and lower levels of PINP (M = 49.3 vs. 67.4 mg/L, p = .030).
Our analysis has shown, some cytogenetic changes, especially delRB1, t(14;16) and 1q21gain, which affect the components of the cytokine network in multiple myeloma.
本研究旨在探讨多发性骨髓瘤（MM）患者血清骨代谢标志物和骨髓微环境与细胞遗传学变化的相关性。
我们评估了 308 例患者的细胞遗传学变化，并将其与以下骨髓代谢水平相关联：胸苷激酶（TK）、β2-微球蛋白（b-2-m）、Dickkopf-1 蛋白（DKK-1）、I 型胶原 C 端肽（ICTP）、I 型前胶原 N 端肽（PINP）、白细胞介素 6 受体（rIL-6）、血管细胞黏附分子-1（VCAM）、可溶性细胞间黏附分子-1、骨保护素（OPG）、肝细胞生长因子（HGF）、血管内皮生长因子（VEGF）、黏附素-1（SYN-1）和 Fas 抗原。
delRB1 个体的 OPG 水平较低（M=7.39 vs. 5.46 pmol/L，p=.025），VEGF 水平较低（M=304 vs. 196 pg/ml；p=.036）。t(14;16)与较高的β2m 水平相关（M=7.59 vs. 4.13 mg/L；p=.022），与较低的 DKK-1 水平相关（M=4465 ng/L vs. 12593）。1q21 获得与较高的 TK 水平相关（M=100.0 vs. 11.0 IU/L，p=.026），与较低的 PINP 水平相关（M=49.3 vs. 67.4 mg/L，p=.030）。
我们的分析表明，某些细胞遗传学变化，特别是 delRB1、t(14;16)和 1q21 获得，影响多发性骨髓瘤中细胞因子网络的组成部分。
