Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Psychosomatic Medicine and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Eur Eat Disord Rev. 2022 Jul;30(4):341-352. doi: 10.1002/erv.2894. Epub 2022 Mar 20.
Previous diffusion tensor imaging studies reported a reduced fractional anisotropy in the body of the corpus callosum in patients with anorexia nervosa, which may indicate impaired white matter integrity in interhemispheric connections. The aim of the current study was to investigate whether structural connectivity is affected in patients with anorexia nervosa.
To this end, we compared the number of streamlines (a model of the white matter fibre tracts) and the total volume filled by these streamlines in different subsections of the corpus callosum in 33 women with and 33 without anorexia nervosa as well as in 20 recovered individuals.
The volume of streamlines in the anterior and mid-anterior subsection of the corpus callosum was reduced in women with, but not in those who had recovered from anorexia nervosa. No differences in number of streamlines was detected in the corpus callosum between patients with anorexia nervosa, healthy controls and recovered patients.
Alterations of the corpus callosum have been repeatedly reported in anorexia nervosa. Since the recovered group did not differ from the healthy control group, the reported alterations in acute patients appear to represent a state and not a trait marker.
先前的弥散张量成像研究报告称，厌食症患者胼胝体体部的各向异性分数降低，这可能表明大脑两半球间连接的白质完整性受损。本研究旨在探讨厌食症患者的结构连接是否受到影响。
为此，我们比较了 33 名厌食症患者和 33 名无厌食症患者以及 20 名已康复患者的胼胝体不同节段的流线数量（白质纤维束的模型）和这些流线填充的总体积。
在患有厌食症的女性中，胼胝体前和中前部的流线体积减少，但在已从厌食症中康复的女性中没有减少。在胼胝体中，没有发现厌食症患者、健康对照组和已康复患者之间的流线数量存在差异。
厌食症患者的胼胝体发生了反复变化。由于康复组与健康对照组没有差异，因此在急性患者中报告的变化似乎代表了一种状态而不是特征标记。
