Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100091, China.
Key Laboratory of Animal Models and Human Disease Mechanism of Chinese Academy of Science & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Yi Chuan. 2022 Mar 20;44(3):189-197. doi: 10.16288/j.yczz.21-427.
Alzheimer's disease (AD) is the common neurodegenerative disease in the center never system and the typical dementia in old people. The major pathological changes of AD are the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tangles, loss of cholinergic neurons, inflammation and metabolism dysfunction. However, the molecular mechanism leading to AD pathogenesis is not clear. More and more studies reported that long non-coding RNAs (lncRNAs) play important roles in AD. In this review, we briefly introduce the recent research progress on lncRNAs in AD, including their regulation of clearance of the Aβ plaques, synaptic function, inflammation reaction and mitochondrial function, and thus providing the references for that lncRNAs can serve as a potential diagnostic biomarker and therapeutic target in AD.
阿尔茨海默病（AD）是中枢神经系统常见的神经退行性疾病，也是老年人中典型的痴呆症。AD 的主要病理变化是淀粉样β（Aβ）斑块、神经原纤维缠结、胆碱能神经元丧失、炎症和代谢功能障碍的积累。然而，导致 AD 发病机制的分子机制尚不清楚。越来越多的研究表明，长非编码 RNA（lncRNAs）在 AD 中发挥重要作用。在这篇综述中，我们简要介绍了 lncRNAs 在 AD 中的最新研究进展，包括它们对 Aβ斑块清除、突触功能、炎症反应和线粒体功能的调节，从而为 lncRNAs 可以作为 AD 的潜在诊断生物标志物和治疗靶点提供参考。
