POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Wiad Lek. 2022;75(2):494-498.
The aim: To study the clinical and laboratory characteristics of measles, as well as to compare the course of this disease in vaccinated and unvaccinated children in the Poltava region (Ukraine).
Materials and methods: 104 inpatients with measles were examined: vaccinated (n=27) and unvaccinated (n=77). The patient examination program included: assessment of complaints and anamnestic data obtained by questioning (during admission to hospital treatment, during treatment and after discharge) and detailed analysis of medical records (Form № 003/γ), physical examination, general clinical study of peripheral blood. Statistical processing of the study results was carried out by methods of variation statistics using the program «SPSS 17.0».
Results: The clinical and laboratory picture of measles in the examined patients is typical for this disease. Measles vaccinated children are significantly less likely to have fever (р=0.001) and Koplik's spots (χ2=3.80, р=0.051), the duration of fever (р=0.001), cough (р=0.000), and the length of hospital stay (р=0.000), as well as 3.0 times less often leukopenia is detected (р=0.043) and 2.0 times less often - acceleration of ESR (р=0.023).
Conclusions: The obtained data raise the question of expanding the explanatory work on the importance of a full course of preventive vaccination among children, as well as increasing the volume of public procurement of necessary drugs to increase public access to free vaccination.
研究麻疹的临床和实验室特征，并比较乌克兰波尔塔瓦地区接种和未接种疫苗的儿童的疾病病程。
104 名麻疹住院患者接受了检查：接种组（n=27）和未接种组（n=77）。患者检查方案包括：评估投诉和通过询问获得的病史数据（在住院治疗期间、治疗期间和出院后），并详细分析病历（表格№003/γ），进行体格检查，对周围血进行一般临床研究。使用程序“SPSS 17.0”对研究结果进行了变化统计处理。
检查患者的麻疹临床和实验室表现为该病典型表现。接种麻疹疫苗的儿童发热（р=0.001）和 Koplik 点（χ2=3.80，р=0.051）、发热持续时间（р=0.001）、咳嗽（р=0.000）和住院时间（р=0.000）明显减少，白细胞减少的发生率也低 3 倍（р=0.043），ESR 加速的发生率低 2 倍（р=0.023）。
获得的数据提出了一个问题，即需要扩大关于儿童全程预防接种重要性的解释工作，并增加必要药物的公共采购量，以增加公众获得免费接种的机会。
