Translational Immunology Research Program (TRIMM), Research Programs Unit (RPU), Department of Bacteriology and Immunology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Department of Computer Science, Aalto University, Espoo, Finland.
Eur J Immunol. 2022 Jun;52(6):882-894. doi: 10.1002/eji.202149465. Epub 2022 Mar 30.
Long-term T-cell memory is dependent on the maintenance of memory T cells in the lymphoid tissues, and at the surface interfaces that provide entry routes for pathogens. However, much of the current information on human T-cell memory is based on analyzing circulating T cells. Here, we have studied the distribution and age-related changes of memory T-cell subsets in samples from blood, mesenteric LNs, spleen, and ileum, obtained from donors ranging in age from 5 days to 67 years of age. Our data show that the main reservoir of polyclonal naive cells is found in the LNs, and the resting memory subsets capable of self-renewal are also prominent there. In contrast, nondividing but functionally active memory subsets dominate the spleen, and especially the ileum. In general, the replacement of naive cells with memory subsets continues throughout our period of observation, with no apparent plateau. In conclusion, the analysis of lymphoid and nonlymphoid tissues reveals a dynamic pattern of changes distinct to each tissue, and with substantial differences between CD4 and CD8 compartments.
长期的 T 细胞记忆依赖于淋巴组织中记忆 T 细胞的维持，以及提供病原体进入途径的表面界面。然而，目前关于人类 T 细胞记忆的大部分信息都是基于分析循环 T 细胞得出的。在这里，我们研究了年龄在 5 天至 67 岁之间的供体的血液、肠系膜淋巴结、脾脏和回肠样本中记忆 T 细胞亚群的分布和与年龄相关的变化。我们的数据表明，多克隆幼稚细胞的主要储存库存在于淋巴结中，并且能够自我更新的静止记忆亚群也在那里很突出。相比之下，非分裂但具有功能活性的记忆亚群在脾脏中占据主导地位，特别是在回肠中。总的来说，在我们观察的整个期间，幼稚细胞被记忆亚群取代的过程仍在继续，并没有明显的停滞。总之，对淋巴和非淋巴组织的分析揭示了每种组织都具有独特的动态变化模式，而且 CD4 和 CD8 区室之间存在显著差异。
