位置，位置，位置：小鼠和人类组织驻留记忆 T 细胞。
Location, location, location: Tissue resident memory T cells in mice and humans.
机构信息
Columbia Center for Translational Immunology, Columbia University, New York, NY, USA.
Department of Microbiology and Immunology, Columbia University, New York, NY, USA.
出版信息
Sci Immunol. 2019 Apr 5;4(34). doi: 10.1126/sciimmunol.aas9673.
Abstract
The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity to encompass site-specific responses mediated by tissue-adapted memory T cells throughout the body. Here, we discuss the key phenotypic, transcriptional, and functional features of these tissue-resident memory T cells (T) as established in mouse models of infection and translated to humans by novel tissue sampling approaches. Integration of findings from mouse and human studies may hold the key to unlocking the potential of T for promoting tissue immunity and preventing infection.
摘要
组织驻留记忆 T 细胞的发现改变了我们对适应性免疫的理解，将全身组织适应性记忆 T 细胞介导的组织特异性反应纳入其中。本文讨论了感染小鼠模型中建立的这些组织驻留记忆 T 细胞（T）的关键表型、转录和功能特征，并通过新型组织采样方法将其转化为人类研究。将小鼠和人类研究的结果相结合可能是挖掘 T 促进组织免疫和预防感染潜能的关键。
相似文献
1
Location, location, location: Tissue resident memory T cells in mice and humans.位置，位置，位置：小鼠和人类组织驻留记忆 T 细胞。
Sci Immunol. 2019 Apr 5;4(34). doi: 10.1126/sciimmunol.aas9673.
2
Axes of heterogeneity in human tissue-resident memory T cells.人类组织驻留记忆 T 细胞的异质性轴。
Immunol Rev. 2023 Jul;316(1):23-37. doi: 10.1111/imr.13210. Epub 2023 May 21.
3
Mucosal BCG Vaccination Induces Protective Lung-Resident Memory T Cell Populations against Tuberculosis.黏膜卡介苗接种可诱导针对结核病的具有保护性的肺驻留记忆T细胞群体。
mBio. 2016 Nov 22;7(6):e01686-16. doi: 10.1128/mBio.01686-16.
4
Emerging concepts in tissue-resident T cells: lessons from humans.组织驻留T细胞的新观念：来自人类的经验教训
Trends Immunol. 2015 Jul;36(7):428-35. doi: 10.1016/j.it.2015.05.003. Epub 2015 Jun 10.
5
Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.组织驻留记忆 T 细胞在组织稳态、持续性感染和癌症监测中的作用。
Immunol Rev. 2018 May;283(1):54-76. doi: 10.1111/imr.12650.
6
Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells.组织驻留记忆 T 细胞的长期维持龛位。
Front Immunol. 2018 May 31;9:1214. doi: 10.3389/fimmu.2018.01214. eCollection 2018.
7
T-cell memory in tissues.组织中的 T 细胞记忆。
Eur J Immunol. 2021 Jun;51(6):1310-1324. doi: 10.1002/eji.202049062. Epub 2021 Apr 29.
8
Tissue-resident memory T cells at the center of immunity to solid tumors.组织驻留记忆 T 细胞是实体瘤免疫的核心。
Nat Immunol. 2018 Jun;19(6):538-546. doi: 10.1038/s41590-018-0114-2. Epub 2018 May 18.
9
Resident Memory T Cells in the Tumor Microenvironment.肿瘤微环境中的驻留记忆 T 细胞。
Adv Exp Med Biol. 2020;1273:39-68. doi: 10.1007/978-3-030-49270-0_3.
10
Human lung tissue resident memory T cells in health and disease.健康与疾病状态下人肺组织驻留记忆 T 细胞
Curr Opin Immunol. 2019 Aug;59:101-108. doi: 10.1016/j.coi.2019.05.011. Epub 2019 Jun 29.
引用本文的文献
1
Distinct Immunological Landscapes of HCMV-Specific T Cells in Bone Marrow and Peripheral Blood.骨髓和外周血中巨细胞病毒特异性T细胞的独特免疫格局
Pathogens. 2025 Jul 22;14(8):722. doi: 10.3390/pathogens14080722.
2
Impact of 3D cell culture hydrogels derived from basement membrane extracts or nanofibrillar cellulose on CAR-T cell activation.源自基底膜提取物或纳米纤维纤维素的3D细胞培养水凝胶对CAR-T细胞活化的影响。
iScience. 2025 Jul 30;28(9):113234. doi: 10.1016/j.isci.2025.113234. eCollection 2025 Sep 19.
3
Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 T cells underlies distinct functional potential.组织驻留记忆性和组织驻留耗竭性CD8 T细胞的不同个体发生是其不同功能潜力的基础。
bioRxiv. 2025 Aug 11:2025.08.08.669213. doi: 10.1101/2025.08.08.669213.
4
Mucosal immunity and vaccination strategies: current insights and future perspectives.黏膜免疫与疫苗接种策略：当前见解与未来展望。
Mol Biomed. 2025 Aug 20;6(1):57. doi: 10.1186/s43556-025-00301-7.
5
Phenotypic Analysis of Nasal CD69+ CD4+ Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.伴鼻息肉的嗜酸性粒细胞性慢性鼻-鼻窦炎中鼻腔CD69+ CD4+ 组织驻留记忆T细胞的表型分析
J Rhinol. 2025 Jul;32(2):91-98. doi: 10.18787/jr.2025.00025. Epub 2025 Jul 22.
6
Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing.探索用于伤口愈合单细胞转录组分析的机器学习策略。
Burns Trauma. 2025 May 13;13:tkaf032. doi: 10.1093/burnst/tkaf032. eCollection 2025.
7
A variational deep-learning approach to modeling memory T cell dynamics.一种用于模拟记忆性T细胞动力学的变分深度学习方法。
PLoS Comput Biol. 2025 Jul 24;21(7):e1013242. doi: 10.1371/journal.pcbi.1013242.
8
Combining Intramuscular and Intranasal Immunization With the MF59-Adjuvanted Respiratory Syncytial Virus Pre-Fusion Protein Subunit Vaccine Induces Potent Humoral and Cellular Immune Responses in Mice.将肌内注射和鼻内免疫与MF59佐剂呼吸道合胞病毒预融合蛋白亚单位疫苗相结合可在小鼠中诱导强大的体液免疫和细胞免疫反应。
MedComm (2020). 2025 Jul 15;6(8):e70301. doi: 10.1002/mco2.70301. eCollection 2025 Aug.
9
IL-12 mRNA-LNP promotes dermal resident memory CD4 T cell development.白细胞介素-12信使核糖核酸脂质纳米颗粒促进真皮驻留记忆性CD4 T细胞发育。
NPJ Vaccines. 2025 Jul 16;10(1):154. doi: 10.1038/s41541-025-01213-x.
10
A Modular Bacteriophage T4 Nanoparticle Platform Enables Rapid Design of Dual COVID-19-Flu Mucosal Vaccines.模块化噬菌体T4纳米颗粒平台助力快速设计新冠-流感双价黏膜疫苗。
Small Sci. 2025 Jan 28;5(4):2400580. doi: 10.1002/smsc.202400580. eCollection 2025 Apr.
本文引用的文献
1
Generation and persistence of human tissue-resident memory T cells in lung transplantation.在肺移植中人类组织驻留记忆 T 细胞的产生和持久性。
Sci Immunol. 2019 Mar 8;4(33). doi: 10.1126/sciimmunol.aav5581.
2
Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life.人类肠道 T 细胞免疫的微观解剖揭示了肠道相关淋巴组织在一生中的特定部位变化。
Mucosal Immunol. 2019 Mar;12(2):378-389. doi: 10.1038/s41385-018-0110-8. Epub 2018 Dec 6.
3
Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities.基于染料外排能力的人类组织驻留记忆 T 细胞的功能异质性。
JCI Insight. 2018 Nov 15;3(22):123568. doi: 10.1172/jci.insight.123568.
4
Tissue-resident memory T cells populate the human brain.组织驻留记忆 T 细胞存在于人类大脑中。
Nat Commun. 2018 Nov 2;9(1):4593. doi: 10.1038/s41467-018-07053-9.
5
Prime and target immunization protects against liver-stage malaria in mice.加强针和目标免疫可预防小鼠的肝脏期疟疾。
Sci Transl Med. 2018 Sep 26;10(460). doi: 10.1126/scitranslmed.aap9128.
6
Optimal protection against infection requires noncirculating memory.最佳的抗感染保护需要非循环记忆。
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10416-10421. doi: 10.1073/pnas.1808339115. Epub 2018 Sep 25.
7
Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4 memory T cells that are associated with protection against tuberculosis.肺免疫接种重组流感 A 病毒疫苗可诱导肺驻留 CD4 记忆 T 细胞，与预防结核病相关。
Mucosal Immunol. 2018 Nov;11(6):1743-1752. doi: 10.1038/s41385-018-0065-9. Epub 2018 Aug 16.
8
Human Lymph Nodes Maintain TCF-1 Memory T Cells with High Functional Potential and Clonal Diversity throughout Life.人类淋巴结在整个生命周期中维持具有高功能潜力和克隆多样性的 TCF-1 记忆 T 细胞。
J Immunol. 2018 Oct 1;201(7):2132-2140. doi: 10.4049/jimmunol.1800716. Epub 2018 Aug 15.
9
A Systematic Review: The Role of Resident Memory T Cells in Infectious Diseases and Their Relevance for Vaccine Development.一项系统评价：驻留记忆T细胞在传染病中的作用及其与疫苗开发的相关性
Front Immunol. 2018 Jul 9;9:1574. doi: 10.3389/fimmu.2018.01574. eCollection 2018.
10
Identification and characterization of HIV-specific resident memory CD8 T cells in human lymphoid tissue.鉴定和描述人类淋巴组织中 HIV 特异性常驻记忆 CD8 T 细胞。
Sci Immunol. 2018 Jun 1;3(24). doi: 10.1126/sciimmunol.aar4526.
Zotero 插件