CD4嵌合抗原受体T细胞踏上漫长征程。
CD4 chimeric antigen receptor T cells in for the long journey.
作者信息
Chen Amanda Xy, Derrick Emily B, Beavis Paul A, House Imran G
机构信息
Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.
出版信息
Immunol Cell Biol. 2022 May;100(5):304-307. doi: 10.1111/imcb.12545. Epub 2022 Apr 16.
PMID:35307873
Abstract
In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells isolated from patients over 10 years after therapy, revealing expansion of a long-lived CD4 CAR T-cell population with a cytotoxic phenotype.
摘要
在最近发表的一篇文章中，梅伦霍斯特等人对治疗后10多年从患者体内分离出的嵌合抗原受体（CAR）T细胞进行了纵向分析，发现具有细胞毒性表型的长寿CD4 CAR T细胞群体出现扩增。
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