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氨基缩醛与亲核试剂的反应：一种合成含牛磺酸片段的二（杂）芳基甲烷衍生物的新方法

Reactions of Aminoacetals with -Nucleophiles as a New Method for the Synthesis of Di(het)arylmethane Derivatives with a Taurine Fragment.

作者信息

Smolobochkin A V, Yakhshilikova L J, Bekrenev D D, Gazizov A S, Burilov A R, Pudovik M A

机构信息

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 420088 Kazan, Russia.

Kazan National Research Technological University, 420015 Kazan, Russia.

出版信息

Russ J Gen Chem. 2022;92(2):161-165. doi: 10.1134/S1070363222020049. Epub 2022 Mar 14.

DOI:10.1134/S1070363222020049
PMID:35308085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8921706/
Abstract

Based on the acid-catalyzed reaction of functionalized aminoacetals with -nucleophiles, a series of new diarylmethane derivatives with a taurine fragment were synthesized, the structure of which was established by NMR spectroscopy method.

摘要

基于官能化氨基缩醛与亲核试剂的酸催化反应，合成了一系列带有牛磺酸片段的新型二芳基甲烷衍生物，其结构通过核磁共振光谱法确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fd4/8921706/2f0c71b7ecf6/11176_2022_5748_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fd4/8921706/7814d0131941/11176_2022_5748_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fd4/8921706/2f0c71b7ecf6/11176_2022_5748_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fd4/8921706/7814d0131941/11176_2022_5748_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fd4/8921706/2f0c71b7ecf6/11176_2022_5748_Sch2_HTML.jpg

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Parasite. 2021;28:71. doi: 10.1051/parasite/2021068. Epub 2021 Oct 21.
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Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein.靶向严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白融合肽的小分子进入抑制剂的发现
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Synthesis and Evaluation of Water-Soluble 2-Aryl-1-Sulfonylpyrrolidine Derivatives as Bacterial Biofilm Formation Inhibitors.
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Anthelmintic drugs used in equine species.用于马科动物的驱虫药。
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