Abbott W G, Thuillez P, Howard B V, Bennett P H, Salans L B, Cushman S W, Reaven G M, Foley J E
Diabetes. 1986 Oct;35(10):1077-80. doi: 10.2337/diab.35.10.1077.
Previous studies show that children of women who are diabetic during pregnancy are more obese and have a higher prevalence of non-insulin-dependent diabetes mellitus (NIDDM) than children of women who first developed NIDDM greater than 1 yr after the pregnancy (prediabetic mothers) and children of women who have never developed diabetes (nondiabetic mothers). To determine whether lean and obese children of glucose-intolerant pregnancies can be distinguished from similar children of glucose-tolerant pregnancies, we measured body composition, abdominal and gluteal adipocyte size, fasting free fatty acid (FFA), and fasting and stimulated glucose and insulin concentrations during an oral glucose tolerance test in prepubertal children of glucose-intolerant and prediabetic mothers. Each group ranged in adipocity from 6 to 40% body fat. Age, weight, height, and percentage of body fat were similar in the two groups. There were no significant differences in adipocyte size or in glucose, FFA, C-peptide, and insulin concentrations between the groups. The correlation between abdominal adipocyte size and fasting insulin concentration (r = .91 and .18, t = 2.8, P = .01) was stronger in children from glucose-intolerant than from glucose-tolerant pregnancies, respectively. In terms of the parameters we measured, there are no major differences between children of glucose-intolerant and glucose-tolerant pregnancies.
以往的研究表明，孕期患糖尿病女性的子女比孕期后1年以上首次患非胰岛素依赖型糖尿病（NIDDM）的女性（糖尿病前期母亲）的子女以及从未患糖尿病的女性（非糖尿病母亲）的子女更肥胖，且患非胰岛素依赖型糖尿病的患病率更高。为了确定糖耐量异常孕妇的瘦型和肥胖型子女是否能与糖耐量正常孕妇的类似子女区分开来，我们在糖耐量异常和糖尿病前期母亲的青春期前子女进行口服葡萄糖耐量试验期间，测量了身体成分、腹部和臀部脂肪细胞大小、空腹游离脂肪酸（FFA）以及空腹和刺激后的血糖及胰岛素浓度。每组的肥胖程度在体脂的6%至40%之间。两组的年龄、体重、身高和体脂百分比相似。两组之间在脂肪细胞大小或血糖、FFA、C肽和胰岛素浓度方面没有显著差异。糖耐量异常孕妇的子女中，腹部脂肪细胞大小与空腹胰岛素浓度之间的相关性（r = 0.91和0.18，t = 2.8，P = 0.01）分别比糖耐量正常孕妇的子女更强。就我们测量的参数而言，糖耐量异常和糖耐量正常孕妇的子女之间没有主要差异。
