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一例以吞咽困难为表现的罕见胃肠道淀粉样变性病例。

A Rare Case of Gastrointestinal Amyloidosis Presenting as Dysphagia.

作者信息

Ailawadi Shaina, Cheema Bahar K, Salahuddin Syed, Agrawal Sangeeta

机构信息

Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, USA.

Department of Gastroenterology, Wright State University Boonshoft School of Medicine, Dayton, USA.

出版信息

Cureus. 2022 Feb 10;14(2):e22085. doi: 10.7759/cureus.22085. eCollection 2022 Feb.

DOI:10.7759/cureus.22085
PMID:35308673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8920811/
Abstract

A 74-year-old male with an unintentional 20-pound weight loss over the past year presented with new-onset dysphagia to solid foods. Esophagogastroduodenoscopy showed a subtle stricture with ill-defined scar tissue-like findings in the distal esophagus and erosions in the antrum of the stomach without masses. Pathologic findings showed the presence of amyloidosis involving the proximal and distal esophagus, as well as gastric mucosa with chronic inflammation and reactive epithelial changes. We present a rare case of dysphagia as the initial presentation of gastrointestinal amyloidosis.

摘要

一名74岁男性，在过去一年中体重意外减轻了20磅，出现了新发性的固体食物吞咽困难。食管胃十二指肠镜检查显示，食管远端有细微狭窄，伴有不明确的瘢痕组织样表现，胃窦有糜烂但无肿块。病理检查结果显示存在淀粉样变性，累及食管近端和远端以及胃黏膜，伴有慢性炎症和反应性上皮改变。我们报告了一例罕见的以吞咽困难为首发表现的胃肠道淀粉样变性病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/764da6e31e7b/cureus-0014-00000022085-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/5daa2a175d7e/cureus-0014-00000022085-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/3461a35fd3e2/cureus-0014-00000022085-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/8eb61b101915/cureus-0014-00000022085-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/764da6e31e7b/cureus-0014-00000022085-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/5daa2a175d7e/cureus-0014-00000022085-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/3461a35fd3e2/cureus-0014-00000022085-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/8eb61b101915/cureus-0014-00000022085-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ee/8920811/764da6e31e7b/cureus-0014-00000022085-i04.jpg

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本文引用的文献

1
Primary Gastrointestinal Amyloidosis: An Unusual Cause of Acute Intestinal Pseudo-Obstruction.原发性胃肠道淀粉样变性：急性假性肠梗阻的罕见病因。
Case Rep Gastroenterol. 2019 Nov 1;13(3):462-467. doi: 10.1159/000503897. eCollection 2019 Sep-Dec.
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Clinical and endoscopic manifestations of gastrointestinal amyloidosis: a case series.胃肠道淀粉样变性的临床和内镜表现：病例系列
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Dysphagia revisited: common and unusual causes.再谈吞咽困难：常见及罕见病因
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Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience.胃肠道淀粉样变性：13 年单中心转诊经验。
Haematologica. 2013 Jan;98(1):141-6. doi: 10.3324/haematol.2012.068155. Epub 2012 Jun 24.
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Systemic amyloidosis and the gastrointestinal tract.系统性淀粉样变性与胃肠道
Nat Rev Gastroenterol Hepatol. 2009 Oct;6(10):608-17. doi: 10.1038/nrgastro.2009.147. Epub 2009 Sep 1.
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Review article: gastrointestinal amyloidosis - clinical features, diagnosis and therapy.综述文章：胃肠道淀粉样变性——临床特征、诊断与治疗
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Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis.淀粉样变性患者上消化道的内镜及活检结果
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