Alnaim Abdullah F, Alhawsawi Abrar, AlSomali Abdulaziz, Jannadi Raneem, Alsolami Sana M, Alotaibi Hammam A
Ophthalmology, Dhahran Eye Specialist Hospital, Dhahran, SAU.
Ophthalmology, University of Jeddah, Jeddah, SAU.
Cureus. 2022 Feb 8;14(2):e22023. doi: 10.7759/cureus.22023. eCollection 2022 Feb.
Pediatric-type follicular lymphoma is a disease that affects the lymph nodes of the head and neck in the adult and pediatric patient groups. Ocular involvement is exceedingly rare, especially in the pediatrics age group; therefore, keeping a high clinical suspicion is warranted. Here, we report a rare conjunctival pediatric-type follicular lymphoma in a 15-year-old boy presenting with progressive swelling over the medial aspect of the left bulbar conjunctiva for two months. On examination, the mass was firm, mobile, well encapsulated, wide-based, and had a negative transillumination. An excisional biopsy was performed, and histopathological examination and immunohistochemistry studies revealed lymphoid tissue that was positive for CD20, CD79a, BCL6, and CD10; and negative for BCL2 and MUM1. The CD21 and CD23 positivity highlighted the presence of an expanded follicular dendritic cell meshwork. The patient was diagnosed with conjunctival pediatric-type follicular lymphoma and referred to an oncology center for further examination and treatment. This lymphoma is rare, requiring high clinical suspicion, and thus, reporting the case detail is important and valuable for ophthalmologists and general pediatrics practitioners alike.
儿童型滤泡性淋巴瘤是一种影响成人和儿童患者群体头颈部淋巴结的疾病。眼部受累极为罕见，尤其是在儿科年龄组；因此，保持高度的临床怀疑是必要的。在此，我们报告一例罕见的结膜儿童型滤泡性淋巴瘤，患者为一名15岁男孩，左眼球结膜内侧渐进性肿胀两个月。检查时，肿块质地坚硬、可活动、包膜完整、基底较宽，透照试验阴性。进行了切除活检，组织病理学检查和免疫组织化学研究显示，淋巴组织CD20、CD79a、BCL6和CD10呈阳性；BCL2和MUM1呈阴性。CD21和CD23阳性突出显示存在扩大的滤泡树突状细胞网络。该患者被诊断为结膜儿童型滤泡性淋巴瘤，并被转诊至肿瘤中心进行进一步检查和治疗。这种淋巴瘤很罕见，需要高度的临床怀疑，因此，报告该病例细节对眼科医生和普通儿科医生都很重要且有价值。
