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石墨烯纳米片/二氧化铈纳米片纳米复合材料作为针对多重耐药菌的有效抗菌材料。

Graphene nanoplatelets/CeO nanotiles nanocomposites as effective antibacterial material for multiple drug-resistant bacteria.

作者信息

Rehman Saliha Ur, Niazi Robina Khan, Zulqurnain M, Mansoor Qaisar, Iqbal Javed, Arshad Aqsa

机构信息

Department of Physics, International Islamic University, Islamabad, Pakistan.

Department of Biological Sciences, International Islamic University, Islamabad, Pakistan.

出版信息

Appl Nanosci. 2022;12(6):1779-1790. doi: 10.1007/s13204-022-02422-9. Epub 2022 Mar 14.

DOI:10.1007/s13204-022-02422-9
PMID:35308867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8918601/
Abstract

Antibacterial agents with low toxicity to normal cells, redox activity and free radical scavenging property are urgently needed to address the global health crisis. The phenomenal conducting nature of graphene is a best fit to enhance the antibacterial properties of metal oxides. In this work, CeO nanotiles and graphene nanoplatelets/CeO nanotiles nanocomposites (G/CeO) have been synthesized by a solvothermal method. The prepared materials have been characterized using XRD, FE-SEM, EDX, and UV-visible spectroscopy techniques to investigate their crystallinity, morphology, composition, and optical bandgap energies. The CeO and G/CeO nanocomposites have also been tested for antibacterial applications. The neat CeO nanotiles sample inhibits the bacterial growth of and up to 14.21% and 39.53% respectively. The antibacterial activity was tremendously enhanced using 25% graphene-loaded sample (G/CeO-II) i.e., approximately 83% loss of and 89% in case of has been observed. This can be attributed to the unique nano-architecture, oxidative stress due to the excellent ability of reversible conversion between the two electronic states of CeO and the stress exerted by the planar graphene and CeO nanotiles. Therefore, the G/CeO nanocomposites can find potential application as nano-antibiotics for controlling pathogens.

摘要

为应对全球健康危机，迫切需要对正常细胞毒性低、具有氧化还原活性和自由基清除特性的抗菌剂。石墨烯非凡的导电性质非常适合增强金属氧化物的抗菌性能。在这项工作中，通过溶剂热法合成了CeO纳米片和石墨烯纳米片/CeO纳米片纳米复合材料（G/CeO）。使用X射线衍射（XRD）、场发射扫描电子显微镜（FE-SEM）、能谱仪（EDX）和紫外可见光谱技术对制备的材料进行了表征，以研究它们的结晶度、形态、组成和光学带隙能量。CeO和G/CeO纳米复合材料也进行了抗菌应用测试。纯CeO纳米片样品分别抑制大肠杆菌和金黄色葡萄球菌的生长达14.21%和39.53%。使用25%石墨烯负载样品（G/CeO-II）时，抗菌活性得到极大增强，即观察到大肠杆菌的生长损失约83%，金黄色葡萄球菌的生长损失89%。这可归因于独特的纳米结构、由于CeO两种电子态之间出色的可逆转换能力产生的氧化应激以及平面石墨烯和CeO纳米片施加的应力。因此，G/CeO纳米复合材料可作为控制病原体的纳米抗生素找到潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/8f4e968eff26/13204_2022_2422_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/e73f85455fe8/13204_2022_2422_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/6dc888d245f6/13204_2022_2422_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/bd9c2d8248f0/13204_2022_2422_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/985984436d39/13204_2022_2422_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/8f4e968eff26/13204_2022_2422_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/e73f85455fe8/13204_2022_2422_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/88f3b905f3dc/13204_2022_2422_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/d30667582e95/13204_2022_2422_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/1f77d11d3156/13204_2022_2422_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/6dc888d245f6/13204_2022_2422_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/bd9c2d8248f0/13204_2022_2422_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/985984436d39/13204_2022_2422_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae6c/8918601/8f4e968eff26/13204_2022_2422_Fig8_HTML.jpg

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