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以光激发的钠曙红Y作为直接氢原子转移（HAT）催化剂，通过可见光诱导的自由基缩合环化反应合成3,4-二氢嘧啶-2-(1)-酮/硫酮。

Visible-Light-Induced Radical Condensation Cyclization to Synthesize 3,4-Dihydropyrimidin-2-(1)-ones/thiones Using Photoexcited Na Eosin Y as a Direct Hydrogen Atom Transfer (HAT) Catalyst.

作者信息

Mohamadpour Farzaneh

机构信息

School of Engineering, Apadana Institute of Higher Education, Shiraz7187985443, Iran.

出版信息

ACS Omega. 2022 Mar 3;7(10):8429-8436. doi: 10.1021/acsomega.1c05808. eCollection 2022 Mar 15.

DOI:10.1021/acsomega.1c05808
PMID:35309418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8928547/
Abstract

The data suggests that Na eosin Y-derived photoinduced states act as a HAT catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1)-ones/thiones in ethanol at room temperature. This research establishes a novel function for using a nonmetallic natural dye, Na eosin Y, available commercially and at a cheap cost in the photochemical synthesis using the least amount of catalyst, obtaining good results, speeding up the process, and achieving a high atom economy. The TON and TOF of 3,4-dihydropyrimidin-2-(1)-ones/thiones are computed. Furthermore, this cycle runs on the gram scale as well, indicating the possibility of industrial purposes.

摘要

数据表明，在室温下的乙醇中，曙红Y钠衍生的光致态作为3,4-二氢嘧啶-2-(1)-酮/硫酮合成的氢原子转移（HAT）催化剂。本研究确立了一种新功能，即使用市售且成本低廉的非金属天然染料曙红Y钠，在光化学合成中使用最少的催化剂，获得了良好的效果，加快了反应进程，并实现了高原子经济性。计算了3,4-二氢嘧啶-2-(1)-酮/硫酮的转化数（TON）和转化频率（TOF）。此外，该循环也能在克级规模上运行，表明了其用于工业目的的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/d957f4bce8e2/ao1c05808_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/7513e9bc117e/ao1c05808_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/ddf262ed3a45/ao1c05808_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/a83103428ac9/ao1c05808_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/e7125178dfb0/ao1c05808_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/a3cc67a6dd60/ao1c05808_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/d957f4bce8e2/ao1c05808_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/7513e9bc117e/ao1c05808_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/ddf262ed3a45/ao1c05808_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/a83103428ac9/ao1c05808_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/e7125178dfb0/ao1c05808_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/a3cc67a6dd60/ao1c05808_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffb5/8928547/d957f4bce8e2/ao1c05808_0007.jpg

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