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Functional insights into nucleotide-metabolizing ectoenzymes expressed by bone marrow-resident cells in patients with multiple myeloma.多发性骨髓瘤患者骨髓细胞表达的核苷酸代谢胞外酶的功能见解。
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The Genetic and Molecular Drivers of Multiple Myeloma: Current Insights, Clinical Implications, and the Path Forward.多发性骨髓瘤的遗传和分子驱动因素：当前见解、临床意义及未来方向
Pharmgenomics Pers Med. 2024 Dec 21;17:573-609. doi: 10.2147/PGPM.S350238. eCollection 2024.
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In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy.利用脂质-聚合物纳米粒进行体内骨髓微环境 siRNA 递送来治疗多发性骨髓瘤。
Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2215711120. doi: 10.1073/pnas.2215711120. Epub 2023 Jun 13.
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Smoldering multiple myeloma: evolving diagnostic criteria and treatment strategies.冒烟型多发性骨髓瘤：不断演变的诊断标准与治疗策略。
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):673-681. doi: 10.1182/hematology.2021000304.

本文引用的文献

1
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma.单细胞 RNA 测序揭示多发性骨髓瘤前体阶段免疫微环境受损。
Nat Cancer. 2020 May;1(5):493-506. doi: 10.1038/s43018-020-0053-3. Epub 2020 Apr 27.
2
Immunotherapy Combinations in Multiple Myeloma - Known Unknowns.多发性骨髓瘤中的免疫疗法联合应用——已知与未知
N Engl J Med. 2018 Nov 8;379(19):1791-1795. doi: 10.1056/NEJMp1803602.
3
TIGIT immune checkpoint blockade restores CD8 T-cell immunity against multiple myeloma.TIGIT 免疫检查点阻断恢复了针对多发性骨髓瘤的 CD8 T 细胞免疫。
Blood. 2018 Oct 18;132(16):1689-1694. doi: 10.1182/blood-2018-01-825265. Epub 2018 Jul 9.
4
Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression.阻断 IFNAR1 可抑制多发性骨髓瘤驱动的 Treg 扩增和免疫抑制。
J Clin Invest. 2018 Jun 1;128(6):2487-2499. doi: 10.1172/JCI88169. Epub 2018 May 14.
5
Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment.失调的白细胞介素-18 是多发性骨髓瘤微环境中免疫抑制的关键驱动因素，也是一种潜在的治疗靶点。
Cancer Cell. 2018 Apr 9;33(4):634-648.e5. doi: 10.1016/j.ccell.2018.02.007.
6
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.人多发性骨髓瘤骨髓细胞外基质的蛋白质组学特性研究
Leukemia. 2017 Nov;31(11):2426-2434. doi: 10.1038/leu.2017.102. Epub 2017 Mar 27.
7
Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma.靶向 CD38 抑制调节性 T 细胞的诱导和功能，减轻多发性骨髓瘤中的免疫抑制。
Clin Cancer Res. 2017 Aug 1;23(15):4290-4300. doi: 10.1158/1078-0432.CCR-16-3192. Epub 2017 Mar 1.
8
Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study.纳武利尤单抗治疗复发或难治性血液系统恶性肿瘤患者：Ib期研究的初步结果
J Clin Oncol. 2016 Aug 10;34(23):2698-704. doi: 10.1200/JCO.2015.65.9789. Epub 2016 Jun 6.
9
Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade.多发性骨髓瘤导致克隆性 T 细胞免疫衰老：识别潜在的促进肿瘤免疫的新靶点及其对检查点阻断的影响。
Leukemia. 2016 Aug;30(8):1716-24. doi: 10.1038/leu.2016.84. Epub 2016 Apr 22.
10
PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma.肿瘤微环境中PD-L1/PD-1的存在及PD-1阻断在多发性骨髓瘤中的活性
Leukemia. 2015 Oct;29(10):2110-3. doi: 10.1038/leu.2015.79. Epub 2015 Mar 17.

Bone marrow niche in multiple myeloma and its precursor states.

作者信息

Sklavenitis-Pistofidis Romanos, Bustoros Mark, Ghobrial Irene M

机构信息

Center for Prevention of Progression of Blood Cancers, Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, United States.

Harvard Medical School, Boston, United States.

出版信息

Hemasphere. 2019 Jun 30;3(Suppl). doi: 10.1097/HS9.0000000000000246. eCollection 2019 Jun.

DOI:10.1097/HS9.0000000000000246
PMID:35309815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8925690/
Abstract
摘要