• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The impact of spliceosome mutations in MDS.

作者信息

Boultwood Jacqueline, Pellagatti Andrea

机构信息

Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

出版信息

Hemasphere. 2019 Jun 30;3(Suppl). doi: 10.1097/HS9.0000000000000218. eCollection 2019 Jun.

DOI:10.1097/HS9.0000000000000218
PMID:35309818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8925658/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67fb/8925658/4909016ade53/hs9-3-0132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67fb/8925658/4909016ade53/hs9-3-0132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67fb/8925658/4909016ade53/hs9-3-0132-g001.jpg

相似文献

1
The impact of spliceosome mutations in MDS.剪接体突变在骨髓增生异常综合征中的影响。
Hemasphere. 2019 Jun 30;3(Suppl). doi: 10.1097/HS9.0000000000000218. eCollection 2019 Jun.
2
Tumor suppressor microRNAs are downregulated in myelodysplastic syndrome with spliceosome mutations.在伴有剪接体突变的骨髓增生异常综合征中，肿瘤抑制性微小RNA表达下调。
Oncotarget. 2016 Mar 1;7(9):9951-63. doi: 10.18632/oncotarget.7127.
3
The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.剪接因子突变在骨髓增生异常综合征发病机制中的作用。
Adv Biol Regul. 2014 Jan;54:153-61. doi: 10.1016/j.jbior.2013.09.005. Epub 2013 Sep 15.
4
Clinicopathologic characterisation of myeloid neoplasms with concurrent spliceosome mutations and myeloproliferative-neoplasm-associated mutations.伴有剪接体突变和骨髓增殖性肿瘤相关突变的髓系肿瘤的临床病理特征。
J Clin Pathol. 2020 Nov;73(11):728-736. doi: 10.1136/jclinpath-2020-206495. Epub 2020 Mar 26.
5
Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes.剪接因子突变在骨髓增生异常综合征中的独特和趋同后果。
Am J Hematol. 2020 Feb;95(2):133-143. doi: 10.1002/ajh.25673. Epub 2019 Nov 18.
6
Mutations in the Spliceosomal Machinery Genes SRSF2, U2AF1, and ZRSR2 and Response to Decitabine in Myelodysplastic Syndrome.剪接体机制基因SRSF2、U2AF1和ZRSR2的突变与骨髓增生异常综合征对地西他滨的反应
Anticancer Res. 2015 May;35(5):3081-9.
7
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.剪接体突变对骨髓增生异常综合征中 RNA 剪接的影响：失调的基因/通路和临床关联。
Blood. 2018 Sep 20;132(12):1225-1240. doi: 10.1182/blood-2018-04-843771. Epub 2018 Jun 21.
8
A two-step approach for sequencing spliceosome-related genes as a complementary diagnostic assay in MDS patients with ringed sideroblasts.一种用于对环形铁粒幼细胞性骨髓增生异常综合征（MDS）患者进行剪接体相关基因测序的两步法，作为一种补充诊断检测方法。
Leuk Res. 2017 May;56:82-87. doi: 10.1016/j.leukres.2017.01.031. Epub 2017 Feb 4.
9
Preferential occurrence of spliceosome mutations in acute myeloid leukemia with preceding myelodysplastic syndrome and/or myelodysplasia morphology.在伴有既往骨髓增生异常综合征和/或骨髓发育异常形态学的急性髓系白血病中剪接体突变的优先发生情况。
Leuk Lymphoma. 2015;56(8):2301-8. doi: 10.3109/10428194.2014.995648. Epub 2015 Jan 21.
10
Splicing factor mutant myelodysplastic syndromes: Recent advances.剪接因子突变性骨髓增生异常综合征：最新进展。
Adv Biol Regul. 2020 Jan;75:100655. doi: 10.1016/j.jbior.2019.100655. Epub 2019 Sep 19.

引用本文的文献

1
U2AF1 in various neoplastic diseases and relevant targeted therapies for malignant cancers with complex mutations (Review).U2AF1 在各种肿瘤性疾病及相关复杂突变恶性肿瘤的靶向治疗中的作用（综述）。
Oncol Rep. 2024 Jan;51(1). doi: 10.3892/or.2023.8664. Epub 2023 Nov 17.

本文引用的文献

1
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.U2AF1 突变诱导致癌性 IRAK4 异构体并激活髓系恶性肿瘤中的固有免疫途径。
Nat Cell Biol. 2019 May;21(5):640-650. doi: 10.1038/s41556-019-0314-5. Epub 2019 Apr 22.
2
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene .条件性敲入突变剪接因子基因小鼠造血功能受损和白血病的发生。
Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10437-E10446. doi: 10.1073/pnas.1812669115. Epub 2018 Oct 15.
3
Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.
体细胞剪接体突变在骨髓增生异常综合征中诱导的剪接异常和信使 RNA 产生缺陷。
Nat Commun. 2018 Sep 7;9(1):3649. doi: 10.1038/s41467-018-06063-x.
4
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.癌症相关剪接体基因突变的合成致死和趋同生物学效应。
Cancer Cell. 2018 Aug 13;34(2):225-241.e8. doi: 10.1016/j.ccell.2018.07.003.
5
Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.剪接体突变导致骨髓增生异常综合征对 ATR 抑制的 R 环相关敏感性。
Cancer Res. 2018 Sep 15;78(18):5363-5374. doi: 10.1158/0008-5472.CAN-17-3970. Epub 2018 Jul 27.
6
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.剪接体突变对骨髓增生异常综合征中 RNA 剪接的影响：失调的基因/通路和临床关联。
Blood. 2018 Sep 20;132(12):1225-1240. doi: 10.1182/blood-2018-04-843771. Epub 2018 Jun 21.
7
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.H3B-8800，一种口服小分子剪接调节剂，可诱导剪接体突变型癌症致死。
Nat Med. 2018 May;24(4):497-504. doi: 10.1038/nm.4493. Epub 2018 Feb 19.
8
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.高风险剪接因子突变诱导骨髓增生异常综合征的增强 R 环是一种统一机制。
Mol Cell. 2018 Feb 1;69(3):412-425.e6. doi: 10.1016/j.molcel.2017.12.029. Epub 2018 Jan 27.
9
Physiological P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice.生理 P95H 表达导致小鼠造血干细胞功能受损和 RNA 剪接异常。
Blood. 2018 Feb 8;131(6):621-635. doi: 10.1182/blood-2017-01-762393. Epub 2017 Nov 16.
10
Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches.骨髓增生异常综合征中的剪接因子突变：靶基因与治疗方法
Adv Biol Regul. 2018 Jan;67:13-29. doi: 10.1016/j.jbior.2017.09.008. Epub 2017 Sep 22.