剪接体突变在骨髓增生异常综合征中的影响。 - Suppr

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The impact of spliceosome mutations in MDS.

作者信息

Boultwood Jacqueline, Pellagatti Andrea

机构信息

Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

出版信息

Hemasphere. 2019 Jun 30;3(Suppl). doi: 10.1097/HS9.0000000000000218. eCollection 2019 Jun.

DOI:10.1097/HS9.0000000000000218

PMID:35309818

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8925658/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67fb/8925658/4909016ade53/hs9-3-0132-g001.jpg

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Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene .条件性敲入突变剪接因子基因小鼠造血功能受损和白血病的发生。

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Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.体细胞剪接体突变在骨髓增生异常综合征中诱导的剪接异常和信使 RNA 产生缺陷。

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