Department of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Department of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
PeerJ. 2022 Mar 14;10:e13089. doi: 10.7717/peerj.13089. eCollection 2022.
The aim of the study was to evaluate the performance of sudoscan in screening diabetic microvascular complications in patients with type 2 diabete mellitus (T2DM). 515 patients with T2DM aged from 23 to 89 years were included for analysis in our study. The mean age was 60.00 ± 11.37 years and the mean duration of T2DM was 8.44 ± 7.56 years. Electrochemical skin conductance (ESC) in hands and feet was evaluated by SUDOCAN. Diabetic peripheral neuropathy (DPN) was diagnosed in 378 patients (44.3%), diabetic kidney disease (DKD) in 161 patients (31.26%), diabetic retinopathy (DR) in 148 patients (28.74%). Hands and feet ESC was significantly and independently associated with the presence of DPN, DKD and DR. Patients with a lower ESC (<60 µS) had 5.63-fold increased likelihood of having DPN, 4.90-fold increased likelihood of having DKD, 1.01-fold increased likelihood of having DR, than those with a higher ESC. Age, duration of T2DM, smoking, renal function and vibration perception thresholds were negatively correlated with ESC. Sudoscan parameters were correlated with diabetic microvascular complications, especially with DPN. Sudoscan could be an effective screening tool in primary health care for early screening microvascular complications.
本研究旨在评估 sudoscan 在筛查 2 型糖尿病（T2DM）患者糖尿病微血管并发症中的性能。我们的研究纳入了 515 名年龄在 23 岁至 89 岁的 T2DM 患者进行分析。平均年龄为 60.00±11.37 岁，T2DM 的平均病程为 8.44±7.56 年。通过 SUDOCAN 评估手足电化学皮肤电导（ESC）。378 例患者（44.3%）诊断为糖尿病周围神经病变（DPN），161 例患者（31.26%）诊断为糖尿病肾病（DKD），148 例患者（28.74%）诊断为糖尿病视网膜病变（DR）。手足 ESC 与 DPN、DKD 和 DR 的存在显著相关。ESC 较低（<60µS）的患者发生 DPN 的可能性增加 5.63 倍，发生 DKD 的可能性增加 4.90 倍，发生 DR 的可能性增加 1.01 倍，而 ESC 较高的患者发生 DPN、DKD 和 DR 的可能性较低。年龄、T2DM 病程、吸烟、肾功能和振动觉阈值与 ESC 呈负相关。Sudoscan 参数与糖尿病微血管并发症相关，尤其是 DPN。Sudoscan 可作为初级保健中早期筛查微血管并发症的有效筛查工具。
