Department of Gastroenterology, Affiliated Hospital of Hebei Engineering University, Handan 056002, China.
Department of Infectious Diseases, Affiliated Hospital of Hebei Engineering University, Handan 056002, China.
J Healthc Eng. 2022 Mar 9;2022:7848143. doi: 10.1155/2022/7848143. eCollection 2022.
Hepatocellular carcinoma (HCC) is a common malignancy with high mortality, especially in HCC patients with brain metastases (BMS). However, few studies have investigated the risk factors for BMS among HCC patients based on large-scale population. The study involved clinical data of 36,091 patients who met the inclusion criteria from the SEER database, from 2004 to 2016. Univariate analysis and multifactor logistics regression analysis was used to analyze risk factors affecting BMS among HCC patients. This study revealed that BMS occurred in 108 of 36,091 patients, with an incidence of 0.33%. Median survival was 7 months for patients with BMS, but 12 months for patients without BMS. Univariate analysis showed that pathological low differentiation and undifferentiation, lymph node metastasis, no surgical treatment, and no chemotherapy and radiotherapy increased risk of BMS ( < 0.05). Multivariate analysis suggested that no surgical treatment and no chemotherapy or radiotherapy were independent risk factors for BMS ( < 0.001). Our findings highlighted that the independent risk factors for BMS were no surgical treatment, no chemotherapy, and no radiotherapy.
肝细胞癌（HCC）是一种常见的恶性肿瘤，死亡率很高，特别是在合并脑转移（BMS）的 HCC 患者中。然而，基于大规模人群的 HCC 患者发生 BMS 的危险因素研究较少。本研究纳入了 2004 年至 2016 年 SEER 数据库中符合纳入标准的 36091 例患者的临床资料。采用单因素分析和多因素 logistic 回归分析方法分析影响 HCC 患者发生 BMS 的危险因素。本研究显示，36091 例患者中有 108 例发生 BMS，发病率为 0.33%。有 BMS 的患者中位生存时间为 7 个月，而无 BMS 的患者为 12 个月。单因素分析显示，病理低分化和未分化、淋巴结转移、未行手术治疗、未行化疗和放疗均增加了 BMS 的风险（<0.05）。多因素分析提示未行手术治疗和未行化疗或放疗是 BMS 的独立危险因素（<0.001）。本研究结果表明，BMS 的独立危险因素是未行手术治疗、未行化疗和未行放疗。
