Department of Otolaryngology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Zhejiang Taizhou 317000, China.
Operating Room, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Zhejiang Taizhou 317000, China.
J Healthc Eng. 2022 Mar 11;2022:2531671. doi: 10.1155/2022/2531671. eCollection 2022.
The paper aims to combine mathematical statistics to assess the effect of nutritional intervention in the population of nasopharyngeal cancer patients. . After following the inclusion and exclusion criteria, a total of 120 patients with nasopharyngeal carcinoma were selected. All patients are treated with intensity-modulated radiotherapy (IMRT). The nurse collects relevant clinical treatment data during the radiotherapy of the patient. After the patient's radiotherapy, the nurse remeasures the patient's nutritional status indicators. Three months after the completion of radiotherapy, the patient will be reexamined by MRI, and the radiotherapist will assess the patient's radiosensitivity based on the results of the MRI examination. All the blood biochemical indicators and body measurement indicators were also assessed and coordinated with nasopharyngeal carcinoma patients. This study performs multiple linear regression analysis on treatment-related factors that affect nutritional status during radiotherapy.
The experimental results showed that the side effects of radiotherapy are independent influencing factors of nutritional status. Radiotherapy damages the DNA of cells, so that cells cannot continue to divide and grow, and all cells in the treatment area were affected by radiation. The standard radiotherapy treatment is quite long, and the oral cavity, throat, and parotid gland, are all within the irradiation range. In addition to killing the tumor cells, the radiation can also cause certain damage to the surrounding tissues of the tumor. This article takes radiosensitivity as the dependent variable (insensitivity = 0; sensitivity = 1) and takes the nutritional index NI, age, gender, education level, marriage, smoking, chronic disease history, TNM staging, whether the chemotherapy steps are the same or not, GTVnx prescription dose, and the number of radiotherapies as independent variables. AMC, albumin, hemoglobin, serum prealbumin, and transferrin are all correlated with radiosensitivity, which is consistent with the results of most studies. The results of multivariate logistic regression analysis showed that nutritional index (NI) was correlated with the radiosensitivity of nasopharyngeal carcinoma.
Finally, this paper concludes that nutritional intervention has a certain effect on the treatment of patients with nasopharyngeal carcinoma.
本文旨在结合数理统计方法评估营养干预对鼻咽癌患者人群的影响。在遵循纳入和排除标准后，共选择了 120 例鼻咽癌患者。所有患者均接受强度调制放疗（IMRT）。护士在患者放疗期间收集相关临床治疗数据。患者放疗后，护士重新测量患者的营养状况指标。放疗完成 3 个月后，患者将接受 MRI 复查，放射治疗师将根据 MRI 检查结果评估患者的放射敏感性。还评估了所有血液生化指标和身体测量指标，并与鼻咽癌患者相协调。本研究对影响放疗期间营养状况的治疗相关因素进行了多元线性回归分析。
实验结果表明，放疗的副作用是营养状况的独立影响因素。放疗会破坏细胞的 DNA，使细胞无法继续分裂和生长，治疗区域内的所有细胞都受到辐射的影响。标准放疗治疗时间相当长，口腔、喉咙和腮腺都在照射范围内。除了杀死肿瘤细胞外，辐射还会对肿瘤周围组织造成一定的损伤。本文以放射敏感性为因变量（不敏感=0；敏感=1），以营养指数 NI、年龄、性别、教育水平、婚姻状况、吸烟史、慢性病史、TNM 分期、化疗步骤是否相同、GTVnx 处方剂量和放射治疗次数为自变量。AMC、白蛋白、血红蛋白、血清前白蛋白和转铁蛋白均与放射敏感性相关，这与大多数研究的结果一致。多因素逻辑回归分析结果显示，营养指数（NI）与鼻咽癌的放射敏感性相关。
最后，本文得出结论，营养干预对鼻咽癌患者的治疗有一定的效果。
