Weber G, Heitz P U, Pliess G
Hautarzt. 1986 Aug;37(8):458-62.
In previous investigations we observed an increase of growth hormone (HGH) in the blood serum of patients suffering from various clinical forms of psoriasis. The skin lesions disappeared in about 70% when treated systemically with somatostatin and/or bromocriptine, which are inhibitors of HGH secretion. These findings suggested a post mortem investigation of the pituitary glands of 10 patients who had suffered from psoriasis or psoriatic arthritis. Using histochemical and immunochemical methods, we investigated the distribution of cells producing HGH, PRL, LH or FSH. In all 10 pituitary glands we found hyperplasia of the HGH cells, whereas cells producing LH, TSH, FSH and PRL had a normal distribution. The pituitary glands of controls showed no accumulation or hyperplasia of HGH cells.
在先前的研究中，我们观察到患有各种临床类型银屑病的患者血清中生长激素（HGH）水平升高。当用生长抑素和/或溴隐亭进行全身治疗时，约70%的皮肤病变消失，而生长抑素和/或溴隐亭是生长激素分泌的抑制剂。这些发现提示对10例患有银屑病或银屑病关节炎的患者的垂体进行尸检研究。我们采用组织化学和免疫化学方法，研究了产生生长激素、催乳素、促黄体生成素或促卵泡生成素的细胞分布。在所有10个垂体中，我们发现生长激素细胞增生，而产生促黄体生成素、促甲状腺激素、促卵泡生成素和催乳素的细胞分布正常。对照组的垂体未显示生长激素细胞的聚集或增生。
