Albitar-Nehme Sami, Agosta Marilena, Kowalska Agata Helena, Mancinelli Livia, Onori Manuela, Lucignano Barbara, Mattana Giordana, Quagliarella Francesco, Cefalo Maria Giuseppina, Merli Pietro, Locatelli Franco, Perno Carlo Federico, Bernaschi Paola
Microbiology and Immunology Diagnostics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Bambino Gesù Children's Hospital, Rome, Italy.
Faculty of Medical Sciences, University College London, London, United Kingdom.
Front Pediatr. 2022 Mar 3;10:861476. doi: 10.3389/fped.2022.861476. eCollection 2022.
is a very rare opportunistic yeast causing fungal disease in humans, especially in immunocompromised hosts. Here, we describe a new case of isolated from the blood of a pyrexial pediatric patient with refractory acute B cell lymphoblastic leukemia and acute respiratory distress. Prompt diagnosis through early clinical suspicion and appropriate molecular microbiology analysis allowed the yeast to be accurately identified at species level. Subsequent drug susceptibility testing and focused antifungal treatment with voriconazole and amphotericin B led to a complete clinical and mycological resolution of the infection, which represents the second successful case of bloodstream infection described in literature to date.
是一种非常罕见的机会性酵母菌，可导致人类真菌病，尤其是在免疫功能低下的宿主中。在此，我们描述了一例新病例，该酵母菌从一名患有难治性急性B淋巴细胞白血病和急性呼吸窘迫的发热儿科患者的血液中分离出来。通过早期临床怀疑和适当的分子微生物学分析进行快速诊断，使得该酵母菌能够在种水平上得到准确鉴定。随后的药敏试验以及使用伏立康唑和两性霉素B进行针对性抗真菌治疗，导致感染在临床和真菌学上完全消退，这是迄今为止文献中描述的第二例成功的血流感染病例。
