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特发性性早熟女童的成年身高:一项队列研究及预测模型设计

Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model.

作者信息

Mejorado-Molano Francisco Javier, Sanz-Calvo María Luisa, Posada-Ayala Ana, Caballo-Roig Nieves, Gavela-Pérez Teresa, Mahillo-Fernández Ignacio, Soriano-Guillén Leandro

机构信息

Department of Pediatrics, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.

Centro de Salud Palma Norte, Madrid, Spain.

出版信息

Front Endocrinol (Lausanne). 2022 Mar 3;13:852422. doi: 10.3389/fendo.2022.852422. eCollection 2022.

Abstract

INTRODUCTION

Idiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target height and (b) design a mathematical model to predict adult height at diagnosis in female patients with IPA.

MATERIALS AND METHODS

A cohort study of girls with IPA was conducted from the time of IPA diagnosis until adult height. The following data were collected: target height, perinatal history, anthropometric and biochemical variables and bone age at diagnosis, age at Tanner stage 2 and menarcheal age, and adult height. First, we performed a univariate statistical analysis after which we carried out a multiple linear regression analysis using adult height as the dependent variable.

RESULTS

We obtained data from 79 female patients diagnosed with IPA with a mean adult height of 164.6 cm (95% CI: 163.36-165.85 cm). The mean follow-up time was 6.60 years. Average age at Tanner stage 2 was 9.71 years. Mean menarcheal age was 11.64 years. There were no significant differences between target height and adult height. Of the several predictive models designed for these patients, one of them, which included bone age, obtained an value of 71%.

CONCLUSIONS

Although slightly advanced puberty was observed among the girls with IPA, their adult height was preserved. The use of predictive models of adult height on diagnosis of IPA could facilitate closer follow-up of girls at risk of reduced adult height.

摘要

引言

特发性性早熟(IPA)被认为是青春期的一种正常变异,在女性患者中更为常见。人们担心IPA是否会影响这些女孩的最终身高。我们的主要目标是:(a)比较患有IPA的女孩的成人身高与其目标身高;(b)设计一个数学模型来预测IPA女性患者诊断时的成人身高。

材料与方法

对患有IPA的女孩进行了一项队列研究,从IPA诊断时开始直至达到成人身高。收集了以下数据:目标身高、围产期病史、人体测量和生化变量以及诊断时的骨龄、坦纳2期年龄和初潮年龄,以及成人身高。首先,我们进行了单变量统计分析,之后以成人身高作为因变量进行了多元线性回归分析。

结果

我们获得了79例被诊断为IPA的女性患者的数据,其平均成人身高为164.6厘米(95%置信区间:163.36 - 165.85厘米)。平均随访时间为6.60年。坦纳2期的平均年龄为9.71岁。平均初潮年龄为11.64岁。目标身高与成人身高之间无显著差异。在为这些患者设计的几个预测模型中,其中一个包括骨龄的模型,其R值为71%。

结论

尽管观察到患有IPA的女孩青春期略有提前,但她们的成人身高得以保留。在IPA诊断时使用成人身高预测模型有助于对有成人身高降低风险的女孩进行更密切的随访。

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