Thompson T L, Thomas M R
J Clin Psychiatry. 1986 Oct;47 Suppl:31-8.
A number of advances, primarily pharmacologic, have occurred in recent years in the treatment of depression. Some of the recent advances relating to neurotransmitters and other neuropsychiatric factors believed to be related to depression are discussed, including how antidepressants may affect these systems. Some more recently recognized or often overlooked side effects of antidepressants are also discussed, as well as differential side effect profiles. The second generation antidepressants are critiqued and are generally believed to be no better than many of the first generation antidepressants. The usefulness of and indications for tricyclic serum levels and standard neuroendocrine tests for depression are summarized. Recent findings regarding lithium, including augmentation, and monoamine oxidase inhibitors, especially for atypical depressions with panic symptoms, are included, as is the use of psychostimulants, especially for medically ill patients who cannot take other antidepressants.
近年来，抑郁症的治疗取得了一些进展，主要是药理学方面的进展。本文讨论了一些与神经递质及其他被认为与抑郁症相关的神经精神因素有关的最新进展，包括抗抑郁药如何影响这些系统。还讨论了抗抑郁药一些最近才被认识到或经常被忽视的副作用，以及不同的副作用特征。对第二代抗抑郁药进行了批判，一般认为它们并不比许多第一代抗抑郁药更好。总结了三环类药物血清水平和抑郁症标准神经内分泌检测的用途及适应症。包括了关于锂盐（包括增效作用）和单胺氧化酶抑制剂的最新研究结果，特别是用于伴有惊恐症状的非典型抑郁症，还包括了精神兴奋剂的使用，特别是用于无法服用其他抗抑郁药的内科疾病患者。
