From the Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Centers for Disease Control and Prevention.
Sex Transm Dis. 2022 Jul 1;49(7):504-510. doi: 10.1097/OLQ.0000000000001626. Epub 2022 Mar 12.
Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) disproportionately affect men who have sex with men (MSM). Data on the prevalence, anatomical distribution, and correlates of NG and CT infections among MSM in Vietnam are limited.
Between July 2017 and April 2019, MSM 16 years or older without HIV were enrolled into an observational cohort study. Baseline data, including sociodemographics, sexual behavior, and HIV status, were collected. Testing for NG and CT were performed on urine, rectal, and pharyngeal specimens. Multivariate logistic regression models identified factors associated with NG and CT infections at baseline.
In total, 1489 participants underwent NG/CT testing. The median age was 22 years (interquartile range, 20-26 years). There were 424 (28.5%) NG or CT infections: 322 (21.6%) with CT and 173 (11.6%) with NG. Rectal infections were most common for CT (73.9%), whereas pharyngeal infections were most common for NG (70.5%). Independent risk factors for CT or NG infection included ≥2 sex partners in the prior month (adjusted odds ratio [aOR], 2.04; 95% confidence interval [CI], 1.44-2.91), condomless anal sex (aOR, 1.44; 95% CI, 1.12-1.86), and meeting sex partners online (aOR, 1.35; 95% CI, 1.03-1.76). Recent genitourinary or rectal symptoms were not associated with infections.
The overall and extragenital prevalences of NG and CT infections were high within this sample of young MSM without HIV in Hanoi. Testing limited to urethral specimens would have missed nearly three-quarters of CT and NG infections, supporting the need for routine testing at multiple anatomic sites.
淋病奈瑟菌（NG）和沙眼衣原体（CT）在男男性行为者（MSM）中发病率较高。越南 MSM 中 NG 和 CT 感染的流行率、解剖分布和相关因素的数据有限。
2017 年 7 月至 2019 年 4 月，招募了年龄在 16 岁及以上且无 HIV 的 MSM 进入观察性队列研究。收集了包括社会人口统计学、性行为和 HIV 状况在内的基线数据。对尿液、直肠和咽部标本进行 NG 和 CT 检测。多变量逻辑回归模型确定了基线时与 NG 和 CT 感染相关的因素。
共有 1489 名参与者接受了 NG/CT 检测。中位年龄为 22 岁（四分位距，20-26 岁）。有 424 例（28.5%）NG 或 CT 感染：322 例（21.6%）为 CT 感染，173 例（11.6%）为 NG 感染。直肠感染最常见的是 CT（73.9%），而咽部感染最常见的是 NG（70.5%）。CT 或 NG 感染的独立危险因素包括过去一个月有≥2 个性伴侣（调整后的优势比 [aOR]，2.04；95%置信区间 [CI]，1.44-2.91）、无保护的肛交（aOR，1.44；95% CI，1.12-1.86）和通过网络结识性伴侣（aOR，1.35；95% CI，1.03-1.76）。最近的生殖器或直肠症状与感染无关。
在这项没有 HIV 的河内年轻 MSM 样本中，NG 和 CT 感染的总感染率和非生殖器感染率都很高。仅对尿道标本进行检测，将错过近四分之三的 CT 和 NG 感染，这支持在多个解剖部位进行常规检测的必要性。
