Erlenwein Joachim, Diers Martin, Ernst Jennifer, Schulz Friederike, Petzke Frank
Klinik für Anästhesiologie, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.
Klinik für Psychosomatische Medizin und Psychotherapie, LWL-Universitätsklinikum der Ruhr-Universität Bochum, Bochum, Deutschland.
Schmerz. 2023 Jun;37(3):195-214. doi: 10.1007/s00482-022-00629-x. Epub 2022 Mar 21.
Most patients with amputation (up to 80 %) suffer from phantom limb pain postsurgery. These are often multimorbid patients who also have multiple risk factors for the development of chronic pain from a pain medicine perspective. Surgical removal of the body part and sectioning of peripheral nerves result in a lack of afferent feedback, followed by neuroplastic changes in the sensorimotor cortex. The experience of severe pain, peripheral, spinal, and cortical sensitization mechanisms, and changes in the body scheme contribute to chronic phantom limb pain. Psychosocial factors may also affect the course and the severity of the pain. Modern amputation medicine is an interdisciplinary responsibility.
This review aims to provide an interdisciplinary overview of recent evidence-based and clinical knowledge.
The scientific evidence for best practice is weak and contrasted by various clinical reports describing the polypragmatic use of drugs and interventional techniques. Approaches to restore the body scheme and integration of sensorimotor input are of importance. Modern techniques, including apps and virtual reality, offer an exciting supplement to already established approaches based on mirror therapy. Targeted prosthesis care helps to obtain or restore limb function and at the same time plays an important role reshaping the body scheme.
Consequent prevention and treatment of severe postoperative pain and early integration of pharmacological and nonpharmacological interventions are required to reduce severe phantom limb pain. To obtain or restore body function, foresighted surgical planning and technique as well as an appropriate interdisciplinary management is needed.
大多数截肢患者(高达80%)术后会遭受幻肢痛。这些患者通常患有多种疾病,从疼痛医学角度来看,他们也有多种慢性疼痛发生的风险因素。身体部位的手术切除和周围神经的切断会导致传入反馈缺失,随后感觉运动皮层会发生神经可塑性变化。严重疼痛的体验、外周、脊髓和皮层的敏化机制以及身体图式的改变都会导致慢性幻肢痛。社会心理因素也可能影响疼痛的病程和严重程度。现代截肢医学是一项跨学科的职责。
本综述旨在提供近期循证医学和临床知识的跨学科概述。
最佳实践的科学证据薄弱,与之形成对比的是各种描述药物和介入技术多药合用的临床报告。恢复身体图式和整合感觉运动输入的方法很重要。包括应用程序和虚拟现实在内的现代技术为基于镜像疗法的现有方法提供了令人兴奋的补充。有针对性的假肢护理有助于获得或恢复肢体功能,同时在重塑身体图式方面也起着重要作用。
需要对严重的术后疼痛进行持续预防和治疗,并尽早整合药物和非药物干预措施,以减轻严重的幻肢痛。为了获得或恢复身体功能,需要有前瞻性的手术规划和技术以及适当的跨学科管理。