Camilleri M, Thompson D G, Malagelada J R
J Clin Gastroenterol. 1986 Aug;8(4):424-9.
We define the concept of functional dyspepsia and analyze the putative mechanisms involved in its pathogenesis. We consider the evidence for gastroduodenitis, including the relationship of spiral organisms and viruses in this entity, and for functional dyspepsia as a manifestation of gastric secretory dysfunction and upper gut dysmotility. Functional dyspepsia is probably a heterogeneous condition in which multiple etiopathogenetic mechanisms are involved. Nevertheless, patients with functional dyspepsia constitute a sizable fraction of gastroenterological practice and therefore this disorder deserves intense research.
我们定义了功能性消化不良的概念，并分析了其发病机制中可能涉及的机制。我们考量了关于胃十二指肠炎症的证据，包括螺旋菌和病毒在该疾病中的关系，以及功能性消化不良作为胃分泌功能障碍和上消化道动力障碍表现的证据。功能性消化不良可能是一种涉及多种病因发病机制的异质性病症。然而，功能性消化不良患者在胃肠病学临床实践中占了相当大的比例，因此这种疾病值得深入研究。
