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使用双波长锥束光学CT扫描仪对弗里克-二甲酚橙-明胶凝胶进行表征,用于立体定向和动态放射治疗。

Fricke-Xylenol orange-Gelatin gel characterization with dual wavelength cone-beam optical CT scanner for applications in stereotactic and dynamic radiotherapy.

作者信息

Rousseau Alice, Stien Christel, Bordy Jean-Marc, Blideanu Valentin

机构信息

Université Paris-Saclay, CEA, List, Laboratoire National Henri Becquerel (LNE-LNHB), 91120 Palaiseau, France.

出版信息

Phys Med. 2022 May;97:1-12. doi: 10.1016/j.ejmp.2022.03.008. Epub 2022 Mar 21.

Abstract

PURPOSE

This study is about the development of a new dual wavelength reading method of Fricke-Xylenol orange-Gelatin (FXG) gel dosimeters on the Vista16™ optical Computed Tomography (CT) scanner to perform 3D dose distribution measurements in stereotactic and dynamic radiotherapy treatments.

METHODS

The dosimetric characteristics of an optimized FXG gel composition and its optical CT readout have been evaluated. A dual wavelength reading method has been developed on the CT scanner at wavelengths 590 nm and 633 nm. Small-field dose profile measurements with FXG gel and microDiamond (PTW) detectors were compared by γ-index analysis (0.5%/0.5 mm) to validate this method.

RESULTS

This reading method exhibits linear calibration curves in the 0-4 Gy and 2-10 Gy dose ranges at 590 nm and 633 nm respectively. The absorbed dose values below 4 Gy, measured at 590 nm, and those above 4 Gy, measured at 633 nm, are combined to plot a complete profile. A γ passing rate of 93.4% was achieved.

CONCLUSIONS

The new reading method of FXG gel dosimeters has been implemented on the Vista16™ scanner to span absorbed doses representative of stereotactic and dynamic radiotherapy treatments and enable 3D measurements in tumor volumes and surrounding healthy tissues. Small-field profile measurements validated this reading method as FXG gel dosimeters and microDiamond detectors were in very close agreement. This dosimetric method is a promising candidate for 3D quality assurance end-to-end tests in stereotactic and dynamic radiotherapy.

摘要

目的

本研究旨在开发一种新的双波长读取方法,用于在Vista16™光学计算机断层扫描(CT)扫描仪上对弗里克-二甲酚橙-明胶(FXG)凝胶剂量计进行读取,以在立体定向和动态放射治疗中进行三维剂量分布测量。

方法

评估了优化后的FXG凝胶组合物的剂量学特性及其光学CT读出。已在CT扫描仪上开发了一种在590nm和633nm波长下的双波长读取方法。通过γ指数分析(0.5%/0.5mm)比较了使用FXG凝胶和微型金刚石(PTW)探测器进行的小场剂量分布测量,以验证该方法。

结果

该读取方法在590nm和633nm波长下分别在0 - 4Gy和2 - 10Gy剂量范围内呈现线性校准曲线。将在590nm处测量的低于4Gy的吸收剂量值与在633nm处测量的高于4Gy的吸收剂量值相结合,绘制出完整的剂量分布曲线。γ通过率达到了93.4%。

结论

FXG凝胶剂量计的新读取方法已在Vista16™扫描仪上实现,以涵盖代表立体定向和动态放射治疗的吸收剂量,并能够在肿瘤体积和周围健康组织中进行三维测量。小场剂量分布测量验证了该读取方法,因为FXG凝胶剂量计和微型金刚石探测器的结果非常吻合。这种剂量学方法是立体定向和动态放射治疗中三维质量保证端到端测试的一个有前途的候选方法。

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