中国一家大型精神病医院门诊痴呆患者的性别差异。

Gender differences in outpatients with dementia from a large psychiatric hospital in China.

作者信息

Zhou Jiaojiao, Guo Chengwei, Ren Li, Zhu Dandi, Zhen Wenfeng, Zhang Saina, Zhang Qing'e

机构信息

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, No. 5 Ankang Hutong, Xicheng District, Beijing, 100035, China.

出版信息

BMC Psychiatry. 2022 Mar 21;22(1):208. doi: 10.1186/s12888-022-03852-z.

DOI:10.1186/s12888-022-03852-z

PMID:35313835

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8935692/

Abstract

BACKGROUND

The sociodemographic characteristics and clinical features of dementia patients in psychiatric hospitals have not been thoroughly studied in China. This study aimed to explore the psychiatric outpatient attendance of dementia patients at a psychiatric hospital in China, with particular emphasis on gender differences.

METHODS

This retrospective study examined outpatients with dementia from January 2013 to August 2019 using data in the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) in Beijing Anding Hospital. Age, sex, number of visits, use of drugs and comorbid conditions were extracted from medical records.

RESULTS

Nine thousand four patients were recruited from a specific outpatient clinic of a hospital in Beijing, and the mean number of visits was 6.92. There were 3,433 (38.13%) male patients and 5,571 (61.87%) female patients. The most common comorbidities were generalized anxiety disorder, nonorganic insomnia, delusional disorder and depressive disorder. The proportion of patients using antidementia was the highest, with the rate of 68.3%, followed by benzodiazepines (48.83%), antipsychotics (45.43%), antidepressants (22.24%) and nonbenzodiazepines (19.96%). Patients with dementia showed a significant gender difference in average age (t = 6.36, P < 0.0001). Compared to male patients, female patients had a higher number of visits (7.40 ± 12.90 vs 6.15 ± 10.50, t = 4.81, P < 0.0001). There were significant differences in comorbidity composition between male and female patients (t = 23.09, P < 0.0001).

CONCLUSIONS

Our present findings suggested significant gender differences in the proportion of age, number of visits and comorbidity composition in outpatients with dementia.

摘要

背景

中国尚未对精神病医院中痴呆患者的社会人口学特征和临床特征进行深入研究。本研究旨在探讨中国一家精神病医院中痴呆患者的精神科门诊就诊情况，尤其关注性别差异。

方法

这项回顾性研究利用北京安定医院观察性医疗结局合作组织通用数据模型（OMOP-CDM）中的数据，对2013年1月至2019年8月期间的痴呆门诊患者进行了检查。从病历中提取年龄、性别、就诊次数、药物使用情况和合并症。

结果

从北京一家医院的特定门诊招募了9404名患者，平均就诊次数为6.92次。男性患者3433名（38.13%），女性患者5571名（61.87%）。最常见的合并症为广泛性焦虑障碍、非器质性失眠、妄想性障碍和抑郁症。使用抗痴呆药物的患者比例最高，为68.3%，其次是苯二氮䓬类药物（48.83%）、抗精神病药物（45.43%）、抗抑郁药物（22.24%）和非苯二氮䓬类药物（19.96%）。痴呆患者在平均年龄上存在显著性别差异（t = 6.36，P < 0.0001）。与男性患者相比，女性患者就诊次数更多（7.40 ± 12.90 vs 6.15 ± 10.50，t = 4.81，P < 0.0001）。男性和女性患者在合并症构成上存在显著差异（t = 23.09，P < 0.0001）。