荷兰全科医生中低价值药物治疗:一项回顾性队列研究。

Low-value pharmaceutical care among Dutch GPs: a retrospective cohort study.

机构信息

Radboud Institute for Health Sciences, IQ healthcare, Radboud University Medical Centre, Nijmegen.

Dutch College of General Practitioners, Utrecht.

出版信息

Br J Gen Pract. 2022 Apr 28;72(718):e369-e377. doi: 10.3399/BJGP.2021.0625. Print 2022 May.

Abstract

BACKGROUND

Low-value pharmaceutical care exists in general practice. However, the extent among Dutch GPs remains unknown.

AIM

To assess the prevalence of low-value pharmaceutical care among Dutch GPs.

DESIGN AND SETTING

Retrospective cohort study using data from patient records.

METHOD

The prevalence of three types of pharmaceutical care prescribed by GPs between 2016 and 2019 were examined: topical antibiotics for conjunctivitis, benzodiazepines for non-specific lower back pain, and chronic acid-reducing medication (ARM) prescriptions. Multilevel logistic regression analysis was performed to assess prescribing variation and the influence of patient characteristics on receiving a low-value prescription.

RESULTS

Large variation in prevalence as well as practice variation was observed among the types of low-value pharmaceutical GP care examined. Between 53% and 61% of patients received an inappropriate antibiotics prescription for conjunctivitis, around 3% of patients with lower back pain received an inappropriate benzodiazepine prescription, and 88% received an inappropriate chronic ARM prescription during the years examined. The odds of receiving an inappropriate antibiotic or benzodiazepine prescription increased with age (<0.001), but decreased for chronic inappropriate ARM prescriptions (<0.001). Sex affected only the odds of receiving a non-indicated chronic ARM, with males being at higher risk (<0.001). The odds of receiving an inappropriate ARM increased with increasing neighbourhood socioeconomic status (<0.05). Increasing practice size decreased the odds of inappropriate antibiotic and benzodiazepine prescriptions (<0.001).

CONCLUSION

The results show that the prevalence of low-value pharmaceutical GP care varies among these three clinical problems. Significant variation in inappropriate prescribing exists between different types of pharmaceutical care - and GP practices.

摘要

背景

低价值药物治疗在全科医疗中普遍存在。然而,荷兰全科医生的低价值药物治疗程度尚不清楚。

目的

评估荷兰全科医生低价值药物治疗的流行程度。

设计和设置

使用患者记录中的数据进行回顾性队列研究。

方法

检查 2016 年至 2019 年间全科医生开出的三种类型药物治疗的低价值药物治疗的流行率:结膜炎的局部抗生素、非特异性下腰痛的苯二氮䓬类药物和慢性抑酸药物 (ARM) 处方。进行多水平逻辑回归分析,以评估处方差异以及患者特征对接受低价值处方的影响。

结果

在所检查的三种低价值药物治疗中,普遍存在流行率和实践差异。在接受结膜炎抗生素处方的患者中,约有 53%至 61%接受了不适当的抗生素处方,约 3%的腰痛患者接受了不适当的苯二氮䓬类药物处方,而在检查的几年中,88%的患者接受了不适当的慢性 ARM 处方。接受不适当抗生素或苯二氮䓬类药物处方的几率随着年龄的增长而增加(<0.001),但对于慢性不适当 ARM 处方则降低(<0.001)。性别仅影响非指示性慢性 ARM 的风险比,男性风险更高(<0.001)。接受不适当 ARM 的几率随着邻里社会经济地位的提高而增加(<0.05)。实践规模的增加降低了不适当抗生素和苯二氮䓬类药物处方的几率(<0.001)。

结论

结果表明,这三种临床问题的低价值药物治疗的流行率存在差异。在不同类型的药物治疗-和全科医生实践中,不适当的处方存在显著差异。

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