Department of Ophthalmology, University Hospital Aachen, Aachen, Germany
Department of Ophthalmology, University Hospital Aachen, Aachen, Germany.
Br J Ophthalmol. 2023 Aug;107(8):1098-1103. doi: 10.1136/bjophthalmol-2021-319786. Epub 2022 Mar 21.
BACKGROUND/AIMS: Glaucoma is a chronic disease that requires lifelong monitoring and treatment. However, its control is limited due to discontinuous intraocular pressure (IOP) monitoring related to the practitioners' office hours. Implantable telemetric IOP sensors have made self-measurements possible and provide important information regarding the IOP profiles of patients. However, limited long-term monitoring data are currently available.
In the ARGOS-01 study, a telemetric IOP sensor was implanted in the ciliary sulcus of six patients with open-angle glaucoma during cataract surgery between 2011 and 2012. This study reports telemetric monitoring data collected by self-tonometry and automated measurements and during outpatient visits, including an analysis of one active patient with several years of follow-up. The long-term safety, tolerability and functionality were assessed in the remaining patients during the last visit.
The follow-up period was up to 10 years, in which almost 25 000 IOP measurements were performed. The patients had excellent tolerance of the implanted sensor and did not experience sensor-related discomfort or complications. The active patient reported easy handling of self-tonometry and did not experience long-term restrictions in activities of daily living due to the implanted sensor. Telemetric data provide an insight into patients' measurement routines and IOP fluctuations.
So far, our data suggest good long-term safety, tolerability and functionality of the implanted sensors up to almost ten years. Such sensors may help facilitate patients' self-measurements of IOP. This disease monitoring method should be investigated further to determine if it helps improve wider patient experience, engagement and visual prognosis for those being treated for complex glaucoma.
背景/目的：青光眼是一种慢性疾病，需要终身监测和治疗。然而，由于医生办公室工作时间的限制，眼压（IOP）监测不连续，其控制受到限制。可植入遥测眼压传感器使自我测量成为可能，并为患者的 IOP 曲线提供了重要信息。然而，目前可获得的长期监测数据有限。
在 ARGOS-01 研究中，在 2011 年至 2012 年间，在 6 名开角型青光眼患者的睫状沟中植入了遥测眼压传感器，在白内障手术期间。本研究报告了通过自我眼压测量和自动测量以及门诊就诊期间收集的遥测监测数据，包括对一名具有多年随访的活跃患者的分析。在最后一次就诊时，对其余患者进行了长期安全性、耐受性和功能性评估。
随访时间最长为 10 年，共进行了近 25000 次眼压测量。患者对植入的传感器具有极好的耐受性，并且没有出现与传感器相关的不适或并发症。活跃患者报告说自我眼压测量操作简单，并且由于植入的传感器，日常生活活动没有长期受限。遥测数据提供了对患者测量常规和眼压波动的深入了解。
到目前为止，我们的数据表明，植入传感器的长期安全性、耐受性和功能性良好，最长可达近十年。这种传感器可能有助于促进患者的自我眼压测量。应进一步研究这种疾病监测方法，以确定它是否有助于改善接受复杂青光眼治疗的患者的整体体验、参与度和视觉预后。
