基于加权基因共表达网络分析和癌症基因组图谱临床数据鉴定肾透明细胞癌中铁死亡的共表达枢纽基因。
Identification of co-expression hub genes for ferroptosis in kidney renal clear cell carcinoma based on weighted gene co-expression network analysis and The Cancer Genome Atlas clinical data.
机构信息
National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.
National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, 530021, Guangxi, China.
出版信息
Sci Rep. 2022 Mar 21;12(1):4821. doi: 10.1038/s41598-022-08950-2.
Renal clear cell carcinoma (KIRC) is one of the most common tumors worldwide and has a high mortality rate. Ferroptosis is a major mechanism of tumor occurrence and development, as well as important for prognosis and treatment of KIRC. Here, we conducted bioinformatics analysis to identify KIRC hub genes that target ferroptosis. By Weighted gene co-expression network analysis (WGCNA), 11 co-expression-related genes were screened out. According to Kaplan Meier's survival analysis of the data from the gene expression profile interactive analysis database, it was identified that the expression levels of two genes, PROM2 and PLIN2, are respectively related to prognosis. In conclusion, our findings indicate that PROM2 and PLIN2 may be effective new targets for the treatment and prognosis of KIRC.
肾透明细胞癌（KIRC）是全球最常见的肿瘤之一，死亡率很高。铁死亡是肿瘤发生发展的主要机制，对 KIRC 的预后和治疗也很重要。在这里，我们进行了生物信息学分析，以确定针对铁死亡的 KIRC 枢纽基因。通过加权基因共表达网络分析（WGCNA），筛选出 11 个与共表达相关的基因。根据基因表达谱交互分析数据库的数据的 Kaplan-Meier 生存分析，确定了两个基因 PROM2 和 PLIN2 的表达水平分别与预后相关。总之，我们的研究结果表明，PROM2 和 PLIN2 可能是 KIRC 治疗和预后的有效新靶点。
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