Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
CNS Neurosci Ther. 2022 Jun;28(6):805-817. doi: 10.1111/cns.13828. Epub 2022 Mar 22.
Subarachnoid hemorrhage (SAH) is a common acute and severe disease worldwide, which imposes a heavy burden on families and society. However, the current therapeutic strategies for SAH are unsatisfactory. Hydrogen sulfide (H S), as the third gas signaling molecule after carbon monoxide and nitric oxide, has been widely studied recently. There is growing evidence that H S has a promising future in the treatment of central nervous system diseases. In this review, we focus on the effects of H S in experimental SAH and elucidate the underlying mechanisms. We demonstrate that H S has neuroprotective effects and significantly reduces secondary damage caused by SAH via antioxidant, antiinflammatory, and antiapoptosis mechanisms, and by alleviating cerebral edema and vasospasm. Based on these findings, we believe that H S has great potential in the treatment of SAH and warrants further study to promote its early clinical application.
蛛网膜下腔出血（SAH）是一种常见的全球范围内的急性和重症疾病，给家庭和社会带来了沉重的负担。然而，目前针对 SAH 的治疗策略并不令人满意。硫化氢（H2S）作为继一氧化碳和一氧化氮之后的第三种气体信号分子，最近受到了广泛的研究。越来越多的证据表明 H2S 在治疗中枢神经系统疾病方面具有广阔的前景。在这篇综述中，我们重点关注 H2S 在实验性 SAH 中的作用，并阐明其潜在的机制。我们证明 H2S 具有神经保护作用，并通过抗氧化、抗炎和抗细胞凋亡机制，以及减轻脑水肿和血管痉挛，显著减轻 SAH 引起的继发性损伤。基于这些发现，我们相信 H2S 在治疗 SAH 方面具有巨大的潜力，值得进一步研究以促进其早期临床应用。
