Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Department of Neurosurgery of the People's Hospital of Shiqian, Tongren, Guizhou Province, China.
Med Gas Res. 2024 Jan-Mar;14(1):1-5. doi: 10.4103/2045-9912.379167.
Sevoflurane has become an important volatile anesthetic in clinic and has been widely studied in recent years. Numerous studies have demonstrated the efficacy of sevoflurane in safeguarding against brain damage across various domains. For example, it has played a neuroprotective role in subarachnoid hemorrhage (SAH), traumatic brain injury, and ischemia/reperfusion injury. The ensuing critique will focus on the significance of sevoflurane in experimental SAH and shed light on the underlying mechanisms. The findings of the current investigation demonstrate that sevoflurane possesses neuroprotective capabilities and clarify that it effectively attenuates secondary damage resulting from SAH through anti-inflammatory and anti-apoptotic pathways. More specifically, sevoflurane is observed to mitigate arterial vasospasm, diminish microvascular thrombosis, and alleviate cerebral edema. In light of these discoveries, we maintain that sevoflurane exhibits significant promise in the management of SAH, and it merits additional investigation to facilitate its prompt clinical implementation. Therefore, a thorough understanding of the neuroprotective properties of sevoflurane is beneficial to exploring novel therapeutic solutions for SAH and providing clinicians with alternative treatment modalities.
七氟醚已成为临床重要的挥发性麻醉剂，近年来受到广泛研究。大量研究表明，七氟醚在预防多种领域的脑损伤方面具有疗效。例如，它在蛛网膜下腔出血（SAH）、创伤性脑损伤和缺血/再灌注损伤中发挥了神经保护作用。接下来的批评将集中在七氟醚在实验性 SAH 中的重要性，并阐明其通过抗炎和抗细胞凋亡途径有效减轻 SAH 引起的继发性损伤的潜在机制。本研究的结果表明，七氟醚具有神经保护作用，并证实其通过抗动脉痉挛、减少微血管血栓形成和减轻脑水肿来有效减轻 SAH 引起的继发性损伤。鉴于这些发现，我们认为七氟醚在 SAH 的治疗中具有重要的应用前景，值得进一步研究以促进其迅速临床应用。因此，深入了解七氟醚的神经保护特性有助于探索 SAH 的新治疗方法，并为临床医生提供替代治疗方式。
