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蛋白质复合物组成的质量控制

Quality control of protein complex composition.

作者信息

Padovani Chris, Jevtić Predrag, Rapé Michael

机构信息

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.

出版信息

Mol Cell. 2022 Apr 21;82(8):1439-1450. doi: 10.1016/j.molcel.2022.02.029. Epub 2022 Mar 21.

DOI:10.1016/j.molcel.2022.02.029

PMID:35316660

Abstract

Eukaryotic cells possess hundreds of protein complexes that contain multiple subunits and must be formed at the correct time and place during development. Despite specific assembly pathways, cells frequently encounter complexes with missing or aberrant subunits that can disrupt important signaling events. Cells, therefore, employ several ubiquitin-dependent quality control pathways that can prevent, correct, or degrade flawed complexes. In this review, we will discuss our emerging understanding of such quality control of protein complex composition.

摘要

真核细胞拥有数百种蛋白质复合物，这些复合物包含多个亚基，并且必须在发育过程中的正确时间和地点形成。尽管存在特定的组装途径，但细胞经常会遇到含有缺失或异常亚基的复合物，这些复合物可能会破坏重要的信号传导事件。因此，细胞采用了几种依赖泛素的质量控制途径，这些途径可以预防、纠正或降解有缺陷的复合物。在这篇综述中，我们将讨论我们对蛋白质复合物组成的这种质量控制的新认识。