Bandaru Sai Samyuktha, Capace Ashley, Busa Vishal, Williams Aaron
Internal Medicine, Baton Rouge General Medical Center, Baton Rouge, USA.
Cureus. 2022 Feb 26;14(2):e22620. doi: 10.7759/cureus.22620. eCollection 2022 Feb.
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition caused by excessive immune system activation. HLH can be primary or secondary. Primary HLH is commonly seen in children with underlying genetic mutations, while secondary HLH can be seen at any age. It is usually triggered by inciting factors such as viral infections, patients with underlying rheumatological disease, or malignancies. It has very poor prognosis if left untreated, with survival of only a few months. While there have been around 100 cases of HLH reported during the acute phase of COVID-19 infection, very few post-COVID-19 HLH cases have been reported, only around 35 cases. Here we report a case of a 20-year-old Caucasian male who presented eight weeks after COVID-19 infection with extreme fatigue, fever, lab work concerning for HLH, and a high H score indicating a high probability of HLH. Early identification of HLH following COVID-19 recovery would allow for timely management of the condition.
噬血细胞性淋巴组织细胞增生症（HLH）是一种由免疫系统过度激活引起的危及生命的病症。HLH可分为原发性或继发性。原发性HLH常见于有潜在基因突变的儿童，而继发性HLH可见于任何年龄。它通常由病毒感染、潜在风湿性疾病患者或恶性肿瘤等诱发因素引发。如果不治疗，其预后非常差，生存期仅几个月。虽然在新冠病毒感染急性期报告了约100例HLH病例，但新冠病毒感染后HLH病例报告极少，仅约35例。在此，我们报告一例20岁的白种男性病例，该患者在新冠病毒感染八周后出现极度疲劳、发热、提示HLH的实验室检查结果以及高H评分，表明HLH可能性高。新冠病毒感染康复后早期识别HLH将有助于及时处理该病症。
