Lupinetti F M, Starnes V A, Laws K A, Collins J C, Hammon J W
J Surg Res. 1986 Aug;41(2):146-57. doi: 10.1016/0022-4804(86)90020-x.
The effect of prostacyclin (PGI2) on the myocardium of the awake dog subjected to coronary artery occlusion was examined. Animals were randomly administered PGI2 200 ng/kg/min (n = 6), PGI2 100 ng/kg/min (n = 6), or the vehicle control (n = 6), beginning 30 min prior to coronary artery occlusion. Radiolabeled microspheres (15 microns) were used to measure myocardial blood flow. The myocardial region at risk was determined by fluorescein injection, and infarct size was assessed by triphenyl tetrazolium staining. Segmental myocardial function was evaluated from the systolic ejection shortening (SES) by subendocardial ultrasonic dimension crystals in normal, ischemic, and border zones. PGI2 200 ng/kg/min produced significant decreases in aortic pressure and systemic vascular resistance. PGI2 100 ng/kg/min, which achieves 95% platelet inhibition, had no significant hemodynamic effects. Animals receiving PGI2 200 ng/kg/min had significantly higher blood flow to the ischemic region, better border zones SES, and a smaller infarct. PGI2 ameliorates myocardial injury and reduces functional impairment produced by ischemia in doses that elicit vasodilation. This beneficial effect of PGI2 does not appear to be mediated solely by an antiplatelet mechanism.
研究了前列环素（PGI2）对清醒状态下冠状动脉闭塞犬心肌的影响。在冠状动脉闭塞前30分钟开始，将动物随机给予PGI2 200 ng/kg/分钟（n = 6）、PGI2 100 ng/kg/分钟（n = 6）或赋形剂对照（n = 6）。使用放射性标记的微球（15微米）测量心肌血流量。通过荧光素注射确定危险心肌区域，并通过三苯基四氮唑染色评估梗死面积。通过心内膜下超声尺寸晶体测量正常、缺血和边缘区的收缩期射血缩短（SES）来评估节段性心肌功能。PGI2 200 ng/kg/分钟可使主动脉压和全身血管阻力显著降低。能实现95%血小板抑制的PGI2 100 ng/kg/分钟对血流动力学无显著影响。接受PGI2 200 ng/kg/分钟的动物缺血区域血流量显著更高，边缘区SES更好，梗死面积更小。PGI2在引起血管舒张的剂量下可改善心肌损伤并减少缺血所致的功能损害。PGI2的这种有益作用似乎并非仅由抗血小板机制介导。
