Mareni C, Sessarego M, Coviello D A, Origone P, Ajmar F
Leuk Res. 1986;10(9):1131-7. doi: 10.1016/0145-2126(86)90058-5.
In a patient with chronic myelocytic leukemia chromosome analysis showed a translocation (22;22) (q13;q11). Chromosomes 9 were apparently not involved. Using somatic cell hybrids and a v-abl probe, we demonstrated the translocation of c-abl sequences from chromosome 9 to chromosome 22q-. This confirms the hypothesis that the translocation of c-abl oncogene is essential for the development of Ph1 positive CML.
在一名慢性粒细胞白血病患者中，染色体分析显示存在一种易位，即(22;22)(q13;q11)。9号染色体显然未受累。利用体细胞杂种和v-abl探针，我们证实了c-abl序列从9号染色体易位至22号染色体q-。这证实了如下假说，即c-abl癌基因的易位对于Ph1阳性慢性粒细胞白血病的发生至关重要。
