进行性多发性硬化症中残疾的决定因素
Determinants of Disability in Progressive Onset Multiple Sclerosis.
作者信息
Tütüncü Melih, Tütüncü Mesude, Saip Sabahattin, Siva Aksel
机构信息
Neurology Department, Cerrahpaşa University School of Medicine, İstanbul, Turkey.
Bakırköy Prof. Dr. Mazhar Osman Research and Training Hospital, University of Health Sciences, İstanbul, Turkey.
出版信息
Noro Psikiyatr Ars. 2020 Jun 9;59(1):10-13. doi: 10.29399/npa.25046. eCollection 2022.
INTRODUCTION
To describe the clinical and socio-demographic profiles of the patients with the progressive onset Multiple Sclerosis (MS) and to explore the determinants of disability.
METHOD
This is a retrospective study, which was conducted in a university hospital. Patients with a progressive clinical course at onset were included in the study. In the first analysis, the clinical and demographic properties of the cohort were defined. In the second analysis the effects of age, sex, clinical activity during course, initial clinical symptoms and cerebrospinal fluid analyses on the course were evaluated.
RESULTS
Clinical activity during the course, older age, male gender, medulla spinalis involvement at onset and detection of paraparesis at initial neurological examination was found as a poor prognostic factor.
CONCLUSION
This research confirms previous findings of the studies conducted in populations of Europe and America. Further studies are needed to confirm and validate these findings and to provide greater insight into the effects of ethnic or geographical differences on the course.
引言
描述进行性多发性硬化症（MS）患者的临床和社会人口学特征，并探讨残疾的决定因素。
方法
这是一项在大学医院进行的回顾性研究。发病时临床病程呈进行性的患者被纳入研究。在首次分析中，确定了该队列的临床和人口学特征。在第二次分析中，评估了年龄、性别、病程中的临床活动、初始临床症状和脑脊液分析对病程的影响。
结果
病程中的临床活动、年龄较大、男性、发病时脊髓受累以及初次神经系统检查时发现双下肢轻瘫被发现是不良预后因素。
结论
本研究证实了此前在欧美人群中进行的研究结果。需要进一步的研究来证实和验证这些发现，并更深入地了解种族或地理差异对病程的影响。
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