Soscia Francesca, Ardenti Morini Francesca, Cortis Elisabetta, Ferrari Federica, Civitelli Fortunata S, Marcoccia Antonella
Pediatric Unit, Sant'Eugenio Hospital, ASL Roma 2, Rome, Italy -
Pediatric Unit, Sant'Eugenio Hospital, ASL Roma 2, Rome, Italy.
Minerva Pediatr (Torino). 2022 Mar 23. doi: 10.23736/S2724-5276.22.06800-8.
SARS-CoV2 infection may present at onset with cutaneous manifestations as chilblains, pernio-like lesions characterized by rapid onset, itching, pain and tenderness and quick improvement with re-warming as similarly observed in primary acrocyanosis. The purpose of the present study was to detect in a single institution series of pediatric patients, during COVID-19 pandemic, the prevalence of acrocyanosis compared to previous period and an eventual correlation with SARS-Cov2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection or other secondary etiologies of this disorder.
We retrospectively analyzed the prevalence of pediatric patients with acrocyanosis between January 2020 and July 2021, compared to the same period of previous year. All patients were investigated with capillaroscopies, clinical and laboratory texts. Those patients referred to our Institution, during the Covid-19 pandemic were also examined for SARS-CoV2 serologies to find out an eventual specific correlation with this secondary potential etiology.
During the first wave of Covid-19 pandemic we observed an increased prevalence of this manifestation. The analysis showed that the higher prevalence of patients with acrocyanosis, in this period, was not related to SARS-Cov2 infection.
The acrocyanosis in pediatric patients is rarely associated with rheumatological diseases, being more frequently a primary disorder and strictly related to a sedentary lifestyle.
严重急性呼吸综合征冠状病毒2（SARS-CoV2）感染起病时可能出现皮肤表现，如冻疮、类似佩尼欧病的病变，其特点为起病迅速、瘙痒、疼痛和压痛，且复温后迅速改善，这与原发性手足发绀症的表现相似。本研究的目的是在一家机构的一系列儿科患者中，检测在新冠疫情期间手足发绀症的患病率与此前时期相比的情况，以及与SARS-CoV2（严重急性呼吸综合征冠状病毒2）感染或该病症的其他继发病因之间的潜在关联。
我们回顾性分析了2020年1月至2021年7月期间儿科手足发绀症患者的患病率，并与上一年同期进行比较。所有患者均接受了毛细血管显微镜检查、临床和实验室检查。在新冠疫情期间转诊至我们机构的患者还接受了SARS-CoV2血清学检查，以确定与这种潜在继发病因之间的具体关联。
在新冠疫情的第一波期间，我们观察到这种表现的患病率有所增加。分析表明，在此期间手足发绀症患者较高的患病率与SARS-CoV2感染无关。
儿科患者的手足发绀症很少与风湿性疾病相关，更常见的是一种原发性疾病，且与久坐的生活方式密切相关。
