Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai 200237, China.
Org Lett. 2022 Apr 1;24(12):2299-2304. doi: 10.1021/acs.orglett.2c00410. Epub 2022 Mar 23.
A mild and efficient DBN-mediated addition reaction of α-(trifluoromethyl)styrenes with diazoles, triazoles, tetrazoles, and primary, secondary, and secondary cyclic amines was developed. This practical protocol provided a robust method for the synthesis of various β-trifluoromethyl nitrogen-containing heterocycles and β-trifluoromethyl amines.
发展了一种温和高效的 DBN 介导的α-（三氟甲基）苯乙烯与二唑、三唑、四唑以及伯、仲、仲环胺的加成反应。该实用方案为合成各种β-三氟甲基含氮杂环和β-三氟甲基胺提供了一种稳健的方法。
