一名患有淋巴细胞性漏斗神经垂体炎的17岁男孩，其非酒精性脂肪性肝炎通过生长激素得到有效治疗。
A 17-year-old boy with lymphocytic infundibuloneurohypophysitis who developed non-alcoholic steatohepatitis effectively treated with growth hormone.
作者信息
Takahashi Hidekuni, Nishimata Shigeo, Kumada Atsushi, Yamanaka Gaku, Kashiwagi Yasuyo, Kawashima Hisashi
机构信息
Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan.
出版信息
Endocrinol Diabetes Metab Case Rep. 2022 Mar 1;2022. doi: 10.1530/EDM-21-0148.
SUMMARY
We encountered a case of childhood-onset lymphocytic infundibuloneurohypophysitis, based on the MRI and endocrinological findings, with decreased function of the anterior and posterior lobes of the pituitary. Three years after the diagnosis, the patient developed non-alcoholic steatohepatitis (NASH), which was effectively treated by growth hormone (GH) supplementation. The present case demonstrated that NASH can be effectively treated by short-term GH supplementation, even in late childhood.
LEARNING POINTS
In recent years, the efficacy of growth hormone replacement therapy in normalizing the liver function of adult-onset growth hormone deficiency patients with non-alcoholic steatohepatitis (NASH) has been reported. Lymphocytic infundibuloneurohypophysitis is a very rare disease, particularly in childhood. We here presented a rare case of a child with lymphocytic infundibuloneurohypophysitis who developed NASH and showed substantial improvement in liver function after growth hormone treatment.
摘要
基于磁共振成像（MRI）和内分泌学检查结果，我们确诊了一例儿童期起病的淋巴细胞性漏斗神经垂体炎，该患者垂体前叶和后叶功能均减退。确诊三年后，患者出现非酒精性脂肪性肝炎（NASH），补充生长激素（GH）后得到有效治疗。本病例表明，即使在儿童晚期，短期补充生长激素也可有效治疗NASH。
学习要点
近年来，有报道称生长激素替代疗法对成年期起病的生长激素缺乏且患有非酒精性脂肪性肝炎（NASH）的患者的肝功能正常化具有疗效。淋巴细胞性漏斗神经垂体炎是一种非常罕见的疾病，尤其是在儿童中。我们在此报告了一例罕见的患有淋巴细胞性漏斗神经垂体炎的儿童病例，该患儿出现了NASH，在接受生长激素治疗后肝功能有显著改善。
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