Division of Pediatric Hematology Oncology, Department of Pediatrics.
Division of Rheumatology, Department of Pediatrics, Children's Hospital of Michigan, Central Michigan University College of Medicine, Detroit, MI.
J Pediatr Hematol Oncol. 2022 Apr 1;44(3):e812-e815. doi: 10.1097/MPH.0000000000002370.
The understanding of coronavirus disease 2019 (COVID-19) immune dysregulation is evolving. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with alternations in both innate and adaptive immunity, probably caused by a complex interplay of genetics and environmental exposure with various triggers. A rare hematological complication of SLE as well as recently reported in an adult with COVID-19 is thrombotic thrombocytopenic purpura. We report a pediatric case with features suggestive of the multisystem inflammatory syndrome in children with coronary artery ectasia, thrombotic thrombocytopenic purpura, and new-onset SLE.
对 2019 年冠状病毒病（COVID-19）免疫失调的认识正在不断发展。系统性红斑狼疮（SLE）是一种多系统自身免疫性疾病，固有免疫和适应性免疫均发生改变，可能是由遗传和环境暴露与各种触发因素的复杂相互作用引起的。SLE 的一种罕见血液学并发症，也是最近在 COVID-19 成年患者中报道的，是血栓性血小板减少性紫癜。我们报告了一例儿科病例，其特征提示伴有冠状动脉扩张、血栓性血小板减少性紫癜和新发 SLE 的儿童多系统炎症综合征。
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